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Details on Person UniProt:Q8N684 CPSF7
| Class:Id | ReferenceGeneProduct:72011 |
|---|---|
| _chainChangeLog | chain:1-471 added on Sat February 7 2015 |
| _displayName | UniProt:Q8N684 CPSF7 |
| _timestamp | 2024-11-03 19:45:13 |
| chain | chain:1-471 |
| checksum | 69529E441D742CF9 |
| comment | FUNCTION Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397).SUBUNIT Component of the cleavage factor Im (CFIm) complex which is a heterotetramer composed of two subunits of NUDT21/CPSF5 and two subunits of CPSF6 or CPSF7 or a heterodimer of CPSF6 and CPSF7 (PubMed:20695905, PubMed:23187700, PubMed:8626397, Ref.22). The cleavage factor Im (CFIm) complex associates with the CPSF and CSTF complexes to promote the assembly of the core mRNA 3'-processing machinery (PubMed:29276085). Interacts with NUDT21/CPSF5 (PubMed:29276085). Interacts (via Arg/Ser-rich domain) with FIP1L1 (preferentially via unphosphorylated form and Arg/Glu/Asp-rich region); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF7 hyper-phosphorylation (PubMed:29276085).INTERACTION Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460).ALTERNATIVE PRODUCTS Contains an Arg/Ser-rich domain composed of arginine-serine dipeptide repeats within the C-terminal region that is necessary and sufficient for activating mRNA 3'-processing (PubMed:29276085).PTM Phosphorylated (PubMed:29276085).PTM Asymmetrically dimethylated on arginine residues by PRMT1 (PubMed:20562214).SIMILARITY Belongs to the RRM CPSF6/7 family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: fullName evidence="14"Cleavage and polyadenylation specificity factor subunit 7 alternativeName: Cleavage and polyadenylation specificity factor 59 kDa subunit shortName: CPSF 59 kDa subunit alternativeName: fullName evidence="13"Cleavage factor Im complex 59 kDa subunit shortName evidence="13"CFIm59 alternativeName: Pre-mRNA cleavage factor Im 59 kDa subunit |
| geneName | CPSF7 |
| identifier | Q8N684 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Isopeptide bond Methylation mRNA processing Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CPSF7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992973] ENSEMBL:ENSG00000149532 CPSF7 [Homo sapiens] |
| secondaryIdentifier | CPSF7_HUMAN B3KU04 C9K0Q4 Q7Z3H9 Q9H025 Q9H9V1 |
| sequenceLength | 471 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:225251] UniProt:Q8N684-2 CPSF7 [Homo sapiens] [ReferenceIsoform:411316] UniProt:Q8N684-1 CPSF7 [Homo sapiens] [ReferenceIsoform:8973227] UniProt:Q8N684-3 CPSF7 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:72012] CPSF7 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9715140] CPSF7 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8N684 CPSF7 (72011)
