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Details on Person UniProt:P51003 PAPOLA

Class:Id	ReferenceGeneProduct:71996
_chainChangeLog	chain:1-745 added on Fri February 6 2015;chain:1-745 removed on Wed November 4 2015;initiator methionine:1 added on Wed November 4 2015;chain:2-745 added on Wed November 4 2015;initiator methionine:1 for 71996 removed on Fri Nov 03 2023;initiator methionine: for 71996 added on Fri Nov 03 2023;initiator methionine: for 71996 removed on Fri Aug 15 2025;initiator methionine:1 for 71996 added on Fri Aug 15 2025
_displayName	UniProt:P51003 PAPOLA
_timestamp	2026-02-20 21:42:42
chain	initiator methionine:1 chain:2-745
checksum	14A00CCCDAD9B374
comment	FUNCTION Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus.CATALYTIC ACTIVITY RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphateCOFACTOR Binds 2 magnesium ions. Also active with manganese.SUBUNIT Monomer. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with AHCYL1 and FIP1L1; the interaction with AHCYL1 seems to increase interaction with FIP1L1 (PubMed:19224921). Interacts with NUDT21; the interaction is diminished by acetylation. Interacts with KPNB1; the interaction promotes PAP nuclear import and is inhibited by acetylation of PAP (By similarity).INTERACTION The 90 kDa form is nuclear while the 100 kDa and the 106 kDa forms are both nuclear and cytoplasmic.ALTERNATIVE PRODUCTS Polysumoylated. Varying sumoylation depending on tissue- and cell-type. Highly sumoylated in bladder and NIH 3T3 cells. Sumoylation is required for nuclear localization and enhances PAP stability. Desumoylated by SENP1. Inhibits polymerase activity (By similarity).PTM Hyperphosphorylation on multiple CDK2 consensus and non-consensus sites in the C-terminal Ser/Thr-rich region represses PAP activity in late M-phase. Phosphorylation/dephosphorylation may regulate the interaction between PAP and CPSF (By similarity).PTM Acetylated in the C-terminus. Acetylation decreases interaction with NUDT21 and KPNB1, and inhibits nuclear localization through inhibiting binding to the importin alpha/beta complex (By similarity).SIMILARITY Belongs to the poly(A) polymerase family.
description	recommendedName: Poly(A) polymerase alpha shortName: PAP-alpha ecNumber: 2.7.7.19 alternativeName: Polynucleotide adenylyltransferase alpha
geneName	PAPOLA PAP
identifier	P51003
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing ATP-binding Cytoplasm Isopeptide bond Magnesium Manganese Metal-binding mRNA processing Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding Transferase Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	PAPOLA
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9003707] ENSEMBL:ENSG00000090060 PAPOLA [Homo sapiens]
secondaryIdentifier	PAPOA_HUMAN Q86SX4 Q86TV0 Q8IYF5 Q9BVU2
sequenceLength	745
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:241649] UniProt:P51003-2 PAPOLA [Homo sapiens] [ReferenceIsoform:404261] UniProt:P51003-1 PAPOLA [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:71997] PAPOLA [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4616008] 6SUMO2,3-PAPOLA [nucleoplasm] [Homo sapiens]
(referenceSequence)	[GroupModifiedResidue:4615856] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 445 [GroupModifiedResidue:4615859] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 444 [GroupModifiedResidue:4615904] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 736 [GroupModifiedResidue:4615934] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 662 [GroupModifiedResidue:4615992] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 663 [GroupModifiedResidue:5627414] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 740
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No pathways have been reviewed or authored by UniProt:P51003 PAPOLA (71996)