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Details on Person UniProt:Q9BWJ5 SF3B5
| Class:Id | ReferenceGeneProduct:71978 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-86 added on Sat February 7 2015;initiator methionine:1 for 71978 removed on Fri Nov 03 2023;initiator methionine: for 71978 added on Fri Nov 03 2023;initiator methionine: for 71978 removed on Fri Aug 15 2025;initiator methionine:1 for 71978 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9BWJ5 SF3B5 |
| _timestamp | 2025-08-15 22:04:18 |
| chain | initiator methionine:1 chain:2-86 |
| checksum | B8A209EA9F548E8E |
| comment | FUNCTION Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:28781166, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932).SUBUNIT Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins (PubMed:12234937, PubMed:15146077, PubMed:28781166, PubMed:32494006, PubMed:34822310, PubMed:36797247). Part of the SF3B subcomplex of the 17S U2 SnRNP complex (PubMed:12234937, PubMed:12738865, PubMed:27720643, PubMed:28541300). SF3B associates with the splicing subcomplex SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP) (PubMed:12234937). Within the SF3B subcomplex, interacts directly with SF3B1 (via HEAT domain) and SF3B3 (PubMed:27720643). Component of the minor spliceosome, which splices U12-type introns (PubMed:15146077, PubMed:33509932).INTERACTION Belongs to the SF3B5 family. |
| description | recommendedName: Splicing factor 3B subunit 5 shortName: SF3b5 alternativeName: Pre-mRNA-splicing factor SF3b 10 kDa subunit |
| geneName | SF3B5 SF3B10 |
| identifier | Q9BWJ5 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding Spliceosome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | SF3B5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003819] ENSEMBL:ENSG00000169976 SF3B5 [Homo sapiens] |
| secondaryIdentifier | SF3B5_HUMAN B2R568 Q7RTV1 |
| sequenceLength | 86 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:71979] SF3B5 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9BWJ5 SF3B5 (71978)
