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Details on Person UniProt:Q13435 SF3B2
| Class:Id | ReferenceGeneProduct:71970 |
|---|---|
| _chainChangeLog | chain:1-895 added on Fri February 6 2015 |
| _displayName | UniProt:Q13435 SF3B2 |
| _timestamp | 2024-11-03 20:21:29 |
| chain | chain:1-895 |
| checksum | D372AFA679443AD6 |
| comment | FUNCTION Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932).SUBUNIT Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins (PubMed:11991638, PubMed:12234937, PubMed:15146077, PubMed:32494006, PubMed:34822310, PubMed:36797247). Part of the SF3B subcomplex of the 17S U2 SnRNP complex (PubMed:12234937, PubMed:12738865, PubMed:27720643, PubMed:28541300). SF3B associates with the splicing subcomplex SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP) (PubMed:12234937). Within the SF3B complex, interacts directly with SF3B4 (PubMed:25737013). Found in a complex with PRMT9, SF3B2 and SF3B4 (PubMed:25737013). Interacts (Arg-508-methylated form) with SMN1 (via Tudor domain) (PubMed:25737013). Interacts with RBM7 (PubMed:27905398). Interacts with ERCC6 (PubMed:26030138). Component of the minor spliceosome (PubMed:15146077, PubMed:33509932). Within this complex, interacts with SCNM1 and CRIPT (PubMed:33509932).SUBUNIT (Microbial infection) Interacts with HIV-1 Vpr.INTERACTION Methylation at Arg-508 by PRMT9 is required for the interaction with SMN1.DISEASE The disease is caused by variants affecting the gene represented in this entry.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: Splicing factor 3B subunit 2 alternativeName: Pre-mRNA-splicing factor SF3b 145 kDa subunit shortName: SF3b145 alternativeName: Spliceosome-associated protein 145 shortName: SAP 145 |
| geneName | SF3B2 SAP145 |
| identifier | Q13435 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Coiled coil Direct protein sequencing Disease variant Host-virus interaction Isopeptide bond Methylation mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Spliceosome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SF3B2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993890] ENSEMBL:ENSG00000087365 SF3B2 [Homo sapiens] |
| secondaryIdentifier | SF3B2_HUMAN A8K485 B4DT19 Q7L4T5 Q7Z627 Q969K1 Q96CM6 Q9BWD2 |
| sequenceLength | 895 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:71971] SF3B2 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q13435 SF3B2 (71970)
