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Details on Person UniProt:Q15428 SF3A2

Class:Id	ReferenceGeneProduct:71963
_chainChangeLog	chain:1-464 added on Sat February 7 2015
_displayName	UniProt:Q15428 SF3A2
_timestamp	2024-11-03 20:21:29
chain	chain:1-464
checksum	FA46F064A55EA2CE
comment	FUNCTION Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex (PubMed:29360106, PubMed:29361316, PubMed:30315277). Interacts directly with the duplex formed by U2 snRNA and the intron (PubMed:29360106).SUBUNIT Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins (PubMed:21349847, PubMed:32494006, PubMed:34822310, PubMed:36797247). Part of the SF3A subcomplex of the 17S U2 SnRNP complex which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62 and SF3A1/SAP114 (PubMed:10882114, PubMed:11533230, PubMed:21349847). SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the mature 17S U2 small nuclear ribonucleoprotein complex (17S U2 snRNP) (PubMed:10882114, PubMed:11533230). Identified in the spliceosome 'E' complex, a precursor of the spliceosome 'A' complex (PubMed:10882114). Identified in the spliceosome 'A' and 'B' complexes (PubMed:10882114, PubMed:29360106, PubMed:29361316, PubMed:30315277). Identified in the spliceosome 'C' complex (PubMed:11991638). Interacts with HTATSF1 (PubMed:9710584).INTERACTION Belongs to the SF3A2 family.
description	recommendedName: Splicing factor 3A subunit 2 alternativeName: fullName evidence="16 17"SF3a66 alternativeName: Spliceosome-associated protein 62 shortName: SAP 62
geneName	SF3A2 SAP62
identifier	Q15428
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Direct protein sequencing Metal-binding mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Spliceosome Zinc Zinc-finger
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	SF3A2
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9000840] ENSEMBL:ENSG00000104897 SF3A2 [Homo sapiens]
secondaryIdentifier	SF3A2_HUMAN B2RBU1 D6W605 O75245
sequenceLength	464
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:71964] SF3A2 [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q15428 SF3A2 (71963)