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Details on Person UniProt:P08579 SNRPB2
| Class:Id | ReferenceGeneProduct:71959 |
|---|---|
| _chainChangeLog | chain:1-225 added on Fri February 6 2015 |
| _displayName | UniProt:P08579 SNRPB2 |
| _timestamp | 2024-11-03 20:21:17 |
| chain | chain:1-225 |
| checksum | 67C949CC7E14A92A |
| comment | FUNCTION Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:32494006, PubMed:9716128).SUBUNIT Identified in the spliceosome B complex (PubMed:28781166, PubMed:32494006, PubMed:36797247). Identified in the spliceosome C complex (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:32494006, PubMed:36797247). Present in a spliceosome complex assembled in vitro, and composed of SNRPB2, HPRP8BP and CRNKL1 (PubMed:12084575). Contributes to the binding of stem loop IV of U2 snRNA with SNRPP1 (PubMed:9716128).INTERACTION Patients with systemic lupus erythematosus produce antibodies which interact with snRNP proteins.SIMILARITY Belongs to the RRM U1 A/B'' family. |
| description | recommendedName: U2 small nuclear ribonucleoprotein B'' shortName: U2 snRNP B'' |
| geneName | SNRPB2 |
| identifier | P08579 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ribonucleoprotein RNA-binding Spliceosome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SNRPB2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990954] ENSEMBL:ENSG00000125870 SNRPB2 [Homo sapiens] |
| secondaryIdentifier | RU2B_HUMAN B2R7J3 D3DW21 Q9UJD4 |
| sequenceLength | 225 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:71960] SNRPB2 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P08579 SNRPB2 (71959)
