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Details on Person UniProt:P07910 HNRNPC
| Class:Id | ReferenceGeneProduct:71932 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-306 added on Fri February 6 2015;initiator methionine:1 for 71932 removed on Fri Nov 03 2023;initiator methionine: for 71932 added on Fri Nov 03 2023;initiator methionine: for 71932 removed on Fri Aug 15 2025;initiator methionine:1 for 71932 added on Fri Aug 15 2025 |
| _displayName | UniProt:P07910 HNRNPC |
| _timestamp | 2025-08-15 21:15:24 |
| chain | initiator methionine:1 chain:2-306 |
| checksum | 17BBC78690C69C5C |
| comment | FUNCTION Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).SUBUNIT Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with DHX9; this interaction is direct, enhanced probably by their concomitant binding to RNA and mediates the attachment to actin filaments (PubMed:11687588). Interacts with PPIA/CYPA (PubMed:25678563). Interacts with YWHAE (PubMed:37599448).INTERACTION Component of ribonucleosomes.ALTERNATIVE PRODUCTS Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.PTM Sumoylated. Sumoylation reduces affinity for mRNA.PTM Ubiquitinated and degraded after nucleo-cytoplasmic transport by YWHAE.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the RRM HNRPC family. RALY subfamily.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Heterogeneous nuclear ribonucleoproteins C1/C2 shortName: hnRNP C1/C2 |
| geneName | HNRNPC HNRPC |
| identifier | P07910 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Coiled coil Direct protein sequencing Disease variant Intellectual disability Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein RNA-binding Spliceosome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | HNRNPC |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957712] ENSEMBL:ENSG00000092199 HNRNPC [Homo sapiens] |
| secondaryIdentifier | HNRPC_HUMAN D3DS19 D3DS22 P22628 Q53EX2 Q59FD3 Q5FWE8 Q86SF8 Q86U45 Q96HK7 Q96HM4 Q96IY5 Q9BTS3 |
| sequenceLength | 306 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:153176] UniProt:P07910-2 HNRNPC [Homo sapiens] [ReferenceIsoform:232092] UniProt:P07910-3 HNRNPC [Homo sapiens] [ReferenceIsoform:232093] UniProt:P07910-4 HNRNPC [Homo sapiens] [ReferenceIsoform:402557] UniProt:P07910-1 HNRNPC [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:71933] HNRNPC [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4570543] SUMO1-K250-HNRNPC [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8957764] HNRNPC [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9715136] HNRNPC [cytosol] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:4570456] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 250 |
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No pathways have been reviewed or authored by UniProt:P07910 HNRNPC (71932)
