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Details on Person UniProt:P09651 HNRNPA1

Class:Id	ReferenceGeneProduct:71926
_chainChangeLog	initiator methionine:1 added on Sat February 7 2015;chain:1-372 added on Sat February 7 2015;chain:2-372 added on Sat February 7 2015;initiator methionine:1 for 71926 removed on Fri Nov 03 2023;initiator methionine: for 71926 added on Fri Nov 03 2023;initiator methionine: for 71926 removed on Fri Aug 15 2025;initiator methionine:1 for 71926 added on Fri Aug 15 2025
_displayName	UniProt:P09651 HNRNPA1
_timestamp	2025-08-15 21:48:38
chain	chain:1-372 initiator methionine:1 chain:2-372
checksum	A06683571C6C109F
comment	FUNCTION Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233).FUNCTION (Microbial infection) May play a role in HCV RNA replication.FUNCTION (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis.SUBUNIT Identified in the spliceosome C complex (PubMed:11991638). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with SEPT6 (PubMed:17229681). Interacts with C9orf72 (PubMed:24549040). Interacts with KHDRBS1 (PubMed:17371836). Interacts with UBQLN2 (PubMed:25616961). Interacts with PPIA/CYPA (PubMed:25678563). Interacts (via the RGG-box) with the HOXB-AS3 peptide; the interaction inhibits binding of HNRNPA1 to the intronic sequences flanking exon 9 of the PKM gene, preventing inclusion of exon 9 and promoting inclusion of exon 10 which suppresses formation of the PKM M2 isoform and promotes production of the M1 isoform (PubMed:28985503).SUBUNIT (Microbial infection) Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA.SUBUNIT (Microbial infection) May interact with SARS-CoV Nucleoprotein.INTERACTION Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes (PubMed:17289661).SUBCELLULAR LOCATION (Microbial infection) In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner.SUBCELLULAR LOCATION (Microbial infection) SARS coronavirus-2/SARS-CoV-2 ORF6 protein increases accumulation to the nucleus.ALTERNATIVE PRODUCTS Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine.PTM Sumoylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease may be caused by variants affecting the gene represented in this entry.MISCELLANEOUS Is twenty times more abundant than isoform A1-B.
description	recommendedName: Heterogeneous nuclear ribonucleoprotein A1 shortName: hnRNP A1 alternativeName: Helix-destabilizing protein alternativeName: Single-strand RNA-binding protein alternativeName: hnRNP core protein A1 component recommendedName: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed /component
geneName	HNRNPA1 HNRPA1
identifier	P09651
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Amyotrophic lateral sclerosis Cytoplasm Direct protein sequencing Disease variant Host-virus interaction Isopeptide bond Methylation mRNA processing mRNA splicing mRNA transport Neurodegeneration Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ribonucleoprotein RNA-binding Spliceosome Transport Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	HNRNPA1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8960225] ENSEMBL:ENSG00000135486 HNRNPA1 [Homo sapiens]
secondaryIdentifier	ROA1_HUMAN A8K4Z8 Q3MIB7 Q6PJZ7
sequenceLength	372
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:153135] UniProt:P09651-2 HNRNPA1 [Homo sapiens] [ReferenceIsoform:356446] UniProt:P09651-3 HNRNPA1 [Homo sapiens] [ReferenceIsoform:402656] UniProt:P09651-1 HNRNPA1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:71927] HNRNPA1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8960659] HNRNPA1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9727902] HNRNPA1 [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P09651 HNRNPA1 (71926)