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Details on Person UniProt:P09012 SNRPA
| Class:Id | ReferenceGeneProduct:71914 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-282 added on Sat February 7 2015;initiator methionine:1 for 71914 removed on Fri Nov 03 2023;initiator methionine: for 71914 added on Fri Nov 03 2023;initiator methionine: for 71914 removed on Fri Aug 15 2025;initiator methionine:1 for 71914 added on Fri Aug 15 2025 |
| _displayName | UniProt:P09012 SNRPA |
| _timestamp | 2025-08-15 21:18:58 |
| chain | initiator methionine:1 chain:2-282 |
| checksum | 9426E83EE5A22894 |
| comment | FUNCTION Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.SUBUNIT U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SFPQ; component of a snRNP-free complex with SFPQ. Interacts with IVNS1ABP (via BACK domain); the interaction is indirect (PubMed:30538201).INTERACTION Belongs to the RRM U1 A/B'' family. |
| description | recommendedName: U1 small nuclear ribonucleoprotein A shortName: U1 snRNP A shortName: U1-A shortName: U1A |
| geneName | SNRPA |
| identifier | P09012 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing Methylation mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ribonucleoprotein RNA-binding Spliceosome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | SNRPA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003245] ENSEMBL:ENSG00000077312 SNRPA [Homo sapiens] |
| secondaryIdentifier | SNRPA_HUMAN |
| sequenceLength | 282 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:71915] SNRPA [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P09012 SNRPA (71914)
