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Details on Person UniProt:P62318 SNRPD3

Class:Id	ReferenceGeneProduct:71902
_chainChangeLog	initiator methionine:1 added on Fri February 6 2015;chain:2-126 added on Fri February 6 2015;initiator methionine:1 for 71902 removed on Fri Nov 03 2023;initiator methionine: for 71902 added on Fri Nov 03 2023;initiator methionine: for 71902 removed on Fri Aug 15 2025;initiator methionine:1 for 71902 added on Fri Aug 15 2025
_displayName	UniProt:P62318 SNRPD3
_timestamp	2025-08-15 21:11:15
chain	initiator methionine:1 chain:2-126
checksum	59A6E78E860AA3E0
comment	FUNCTION Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).SUBUNIT Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:10025403, PubMed:11991638, PubMed:19325628, PubMed:21516107, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006, PubMed:36797247). Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (PubMed:10025403, PubMed:19325628, PubMed:21516107, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166). Component of the U1 snRNP (PubMed:19325628, PubMed:25555158). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (PubMed:19325628, PubMed:25555158). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:26912367). Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2 (PubMed:11574479). Component of the minor spliceosome, which splices U12-type introns (PubMed:15146077, PubMed:33509932). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly (PubMed:16314521). Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct (PubMed:10500148, PubMed:11135666, PubMed:12628254).INTERACTION SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.ALTERNATIVE PRODUCTS Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs.MISCELLANEOUS In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity.SIMILARITY Belongs to the snRNP core protein family.
description	recommendedName: Small nuclear ribonucleoprotein Sm D3 shortName: Sm-D3 alternativeName: snRNP core protein D3
geneName	SNRPD3
identifier	P62318
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Methylation mRNA processing mRNA splicing Nucleus Proteomics identification Reference proteome Repeat Ribonucleoprotein RNA-binding Spliceosome
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	SNRPD3
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9000857] ENSEMBL:ENSG00000100028 SNRPD3 [Homo sapiens]
secondaryIdentifier	SMD3_HUMAN B4DJP7 B5BU13 P43331
sequenceLength	126
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8975767] UniProt:P62318-1 SNRPD3 [Homo sapiens] [ReferenceIsoform:8975768] UniProt:P62318-2 SNRPD3 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:71903] SNRPD3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:191781] 2xMe-SNRPD3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:192219] 2xMe-SNRPD3 [nucleoplasm] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:192214] monomethylated residue at unknown position
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No pathways have been reviewed or authored by UniProt:P62318 SNRPD3 (71902)