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Details on Person UniProt:P14678 SNRPB

Class:Id	ReferenceGeneProduct:71895
_chainChangeLog	chain:1-240 added on Sat February 7 2015
_displayName	UniProt:P14678 SNRPB
_timestamp	2024-11-03 20:03:00
chain	chain:1-240
checksum	F2E1D5E11A601170
comment	FUNCTION Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (PubMed:12975319).SUBUNIT Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:10025403, PubMed:11991638, PubMed:19325628, PubMed:21516107, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006, PubMed:36797247). Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (PubMed:10025403, PubMed:19325628, PubMed:21516107, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166). Component of the U1 snRNP (PubMed:19325628, PubMed:25555158). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (PubMed:19325628, PubMed:25555158). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:26912367). Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2 (PubMed:11574479, PubMed:12975319). Component of the minor spliceosome, which splices U12-type introns (PubMed:15146077, PubMed:33509932). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly (PubMed:12095920, PubMed:16314521, PubMed:18984161). Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP (PubMed:18984161). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Interacts with TDRD3 and SNUPN (PubMed:12095920, PubMed:15955813). Interacts with PRMT5; interaction leads to its symmetric arginine dimethylation (By similarity). Interacts with TDRD6; interaction promotes association with PRMT5 (By similarity). Interacts with SMN1; the interaction is direct (PubMed:10500148).INTERACTION SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.ALTERNATIVE PRODUCTS Methylated by PRMT5 (By similarity). Arg-108 and Arg-112 are dimethylated, probably to asymmetric dimethylarginine (PubMed:16087681, Ref.10).DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. B/b' bear Sm epitopes.SIMILARITY Belongs to the snRNP SmB/SmN family.
description	recommendedName: Small nuclear ribonucleoprotein-associated proteins B and B' shortName: snRNP-B alternativeName: Sm protein B/B' shortName: Sm-B/B' shortName: SmB/B'
geneName	SNRPB COD SNRPB1
identifier	P14678
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Cytoplasm Direct protein sequencing Disease variant Intellectual disability Methylation mRNA processing mRNA splicing Nucleus Proteomics identification Reference proteome Repeat Ribonucleoprotein RNA-binding Spliceosome
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	SNRPB
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8994481] ENSEMBL:ENSG00000125835 SNRPB [Homo sapiens]
secondaryIdentifier	RSMB_HUMAN Q15490 Q6IB35 Q9UIS5
sequenceLength	240
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:153353] UniProt:P14678-2 SNRPB [Homo sapiens] [ReferenceIsoform:246614] UniProt:P14678-3 SNRPB [Homo sapiens] [ReferenceIsoform:402964] UniProt:P14678-1 SNRPB [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:71896] SNRPB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:191798] SNRPB [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:192213] Me2-R108,R112-SNRPB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:192218] 2xMe-SNRPB [cytosol] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:192221] symmetric dimethyl-L-arginine at 108 [ModifiedResidue:3341264] symmetric dimethyl-L-arginine at 112
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No pathways have been reviewed or authored by UniProt:P14678 SNRPB (71895)