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Details on Person UniProt:O43172 PRPF4
| Class:Id | ReferenceGeneProduct:71889 |
|---|---|
| _chainChangeLog | chain:1-522 added on Fri February 6 2015 |
| _displayName | UniProt:O43172 PRPF4 |
| _timestamp | 2024-11-03 19:38:19 |
| chain | chain:1-522 |
| checksum | 08975A26D0B21857 |
| comment | FUNCTION Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).SUBUNIT Component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:26912367, PubMed:28781166, PubMed:9257651, PubMed:9328476, PubMed:9404889). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:16723661, PubMed:26912367). Interacts directly with PRPF18, PPIH and PRPF3 (PubMed:12875835, PubMed:25383878, PubMed:9000057, PubMed:9328476, PubMed:9404889). Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA (PubMed:9404889). Interacts with ERCC6 (PubMed:26030138).INTERACTION The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: U4/U6 small nuclear ribonucleoprotein Prp4 alternativeName: PRP4 homolog shortName: hPrp4 alternativeName: U4/U6 snRNP 60 kDa protein alternativeName: WD splicing factor Prp4 |
| geneName | PRPF4 PRP4 |
| identifier | O43172 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Direct protein sequencing Disease variant mRNA processing mRNA splicing Nucleus Proteomics identification Reference proteome Repeat Retinitis pigmentosa Spliceosome WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PRPF4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990341] ENSEMBL:ENSG00000136875 PRPF4 [Homo sapiens] |
| secondaryIdentifier | PRP4_HUMAN O43445 O43864 Q5T1M8 Q96DG2 Q96IK4 |
| sequenceLength | 522 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:152482] UniProt:O43172-2 PRPF4 [Homo sapiens] [ReferenceIsoform:401491] UniProt:O43172-1 PRPF4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:71890] PRPF4 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O43172 PRPF4 (71889)
