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Details on Person UniProt:Q9BUQ8 DDX23
| Class:Id | ReferenceGeneProduct:71878 |
|---|---|
| _chainChangeLog | chain:1-820 added on Sat February 7 2015 |
| _displayName | UniProt:Q9BUQ8 DDX23 |
| _timestamp | 2025-02-21 19:58:09 |
| chain | chain:1-820 |
| checksum | 01DD5BCF8BFBA2DB |
| comment | FUNCTION Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779).CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT The phosphorylated form (by SRPK2) is a component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39 (PubMed:16723661, PubMed:9409622). Identified in the spliceosome C complex (PubMed:11991638). Interacts with ERBB4 (PubMed:20858735). Interacts with ERCC6 (PubMed:26030138).INTERACTION During transcription, accumulates at chromatin loci where unscheduled R-loops form and colocalizes with paused 'Ser-5'-phosphorylated POLR2A/RNA polymerase II and kinase SRPK2.ALTERNATIVE PRODUCTS In vitro phosphorylated by CLK1 and U1 snRNP-associated protein kinase (PubMed:9409622). Phosphorylated by SRPK2 and this phosphorylation is required for its association with the tri-snRNP (U4/U6-U5 tri-small nuclear ribonucleoproteins) and subsequent spliceosomal B complex formation (PubMed:18425142). May be phosphorylated by SRPK2 on Ser residues in the SR domain; the phosphorylation is required for the removal of inappropriate R-loops during transcription (PubMed:28076779).SIMILARITY Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily. |
| description | recommendedName: fullName evidence="13"Probable ATP-dependent RNA helicase DDX23 ecNumber evidence="13"3.6.4.13 alternativeName: 100 kDa U5 snRNP-specific protein alternativeName: DEAD box protein 23 alternativeName: PRP28 homolog alternativeName: U5-100kD |
| geneName | DDX23 |
| identifier | Q9BUQ8 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Chromosome Direct protein sequencing Helicase Hydrolase Isopeptide bond mRNA processing mRNA splicing Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Spliceosome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | DDX23 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004072] ENSEMBL:ENSG00000174243 DDX23 [Homo sapiens] |
| secondaryIdentifier | DDX23_HUMAN B2R600 B4DH15 O43188 |
| sequenceLength | 820 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8969611] UniProt:Q9BUQ8-1 DDX23 [Homo sapiens] [ReferenceIsoform:8969612] UniProt:Q9BUQ8-2 DDX23 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:71879] DDX23 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9BUQ8 DDX23 (71878)
