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Details on Person LDH tetramer reduces PYR to LACT

Class:Id	Reaction:71849
_displayName	LDH tetramer reduces PYR to LACT
_doRelease	TRUE
_timestamp	2024-04-24 07:26:42
catalystActivity	[CatalystActivity:70509] L-lactate dehydrogenase (NAD+) activity of LDH tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643670] L-lactate dehydrogenase activity of LDH tetramer [cytosol] Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9861796] RHEA:23446
input	[SimpleEntity:29398] PYR [cytosol] [SimpleEntity:73473] NADH [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:6807598] Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA) [LiteratureReference:6807523] Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli [LiteratureReference:6808368] Epitopes of human testis-specific lactate dehydrogenase deduced from a cDNA sequence [LiteratureReference:179539] Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase [LiteratureReference:179533] The cDNA and protein sequences of human lactate dehydrogenase B [LiteratureReference:179524] Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4 [LiteratureReference:9861797] The Biochemical and Clinical Perspectives of Lactate Dehydrogenase: An Enzyme of Active Metabolism [LiteratureReference:9861717] Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis
modified	[InstanceEdit:113752] Schmidt, EE, 2004-06-21 10:53:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:179525] D'Eustachio, P, 2006-05-05 20:50:49 [InstanceEdit:450682] D'Eustachio, P, 2009-12-16 [InstanceEdit:450855] D'Eustachio, P, 2009-12-18 [InstanceEdit:6807522] D'Eustachio, Peter, 2015-11-02 [InstanceEdit:6808363] D'Eustachio, Peter, 2015-11-04 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9012031] Jassal, Bijay, 2017-07-10 [InstanceEdit:9032349] Jassal, Bijay, 2017-12-11 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9861803] Stephan, Ralf, 2024-02-21 [InstanceEdit:9862185] Stephan, Ralf, 2024-02-23 [InstanceEdit:9862190] Stephan, Ralf, 2024-02-23 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24
name	LDH tetramer reduces PYR to LACT Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+
negativePrecedingEvent	[NegativePrecedingEvent:9908919] Futile Cycle: LDH tetramer oxidises LACT to PYR
output	[SimpleEntity:29708] LACT [cytosol] [SimpleEntity:29360] NAD+ [cytosol]
precedingEvent	[Reaction:71670] Pyruvate kinase dephosphorylates PEP to PYR [Homo sapiens] [Reaction:71660] Enolase dimers dehydrates 2PG [Homo sapiens] [BlackBoxEvent:163669] Transcriptional activation of PKLR gene by ChREBP:MLX [Homo sapiens] [Reaction:9012036] ME1 tetramer decarboxylates MAL to PYR [Homo sapiens] [Reaction:372843] SLC25A10 mediates exchange of malate and phosphate [Homo sapiens] [Reaction:198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane [Homo sapiens] [Reaction:9861631] ME1 tetramerizes [Homo sapiens] [Reaction:9861660] ME1 tetramer decarboxylates OA to PYR [Homo sapiens] [Reaction:70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp [Homo sapiens] [Reaction:9861631] ME1 tetramerizes [Homo sapiens] [Reaction:70523] PXLP-K314-GPT transaminates L-Ala to form PYR [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:9861807] Negative regulation by 'PolyUb-LDHA [cytosol]'
regulationReference	[RegulationReference:9861794] Negative regulation by 'PolyUb-LDHA [cytosol]' Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis
releaseDate	2004-07-06
reverseReaction	[Reaction:70510] LDH tetramer oxidises LACT to PYR [Homo sapiens] [Reaction:71849] LDH tetramer reduces PYR to LACT [Homo sapiens]
reviewed	[InstanceEdit:9862191] Hill, David P, 2024-02-23
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:450856] D'Eustachio, P, 2009-12-18
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359270] R-HSA-71849.9
structureModified	[InstanceEdit:9861803] Stephan, Ralf, 2024-02-21
summation	[Summation:71741] Cytosolic lactate dehydrogenase (LDH) catalyzes the freely r...
(hasEvent)	[Pathway:70268] Pyruvate metabolism [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9908917] Futile Cycle: LDH tetramer reduces PYR to LACT [Reaction:373875] BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region [Homo sapiens]
(reverseReaction)	[Reaction:70510] LDH tetramer oxidises LACT to PYR [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783925] Update Tracker - [Reaction:71849] LDH tetramer reduces PYR to LACT - v55:[addLiteratureReference, modifyText] [_UpdateTracker:9791140] Update Tracker - [Reaction:71849] LDH tetramer reduces PYR to LACT - v32:[modifyText] [_UpdateTracker:9864314] Update Tracker - [Reaction:71849] LDH tetramer reduces PYR to LACT - v88:[addLiteratureReference, addRegulator, modifyText]
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