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Details on Person G6PC hydrolyzes G6P to Glc and Pi (liver)

Class:IdReaction:71825
_displayNameG6PC hydrolyzes G6P to Glc and Pi (liver)
_doReleaseTRUE
_timestamp2025-01-02 09:28:42
catalystActivity[CatalystActivity:71824] glucose-6-phosphatase activity of G6PC [endoplasmic reticulum membrane]
catalystActivityReference[CatalystActivityReference:9643168] glucose-6-phosphatase activity of G6PC [endoplasmic reticulum membrane] The catalytic center of glucose-6-phosphatase. HIS176 is the nucleophile forming the phosphohistidine-enzyme intermediate during catalysis
compartment[Compartment:17957] endoplasmic reticulum lumen
[Compartment:12045] endoplasmic reticulum membrane
crossReference[DatabaseIdentifier:9933542] RHEA:44905
input[SimpleEntity:113782] G6P [endoplasmic reticulum lumen]
[SimpleEntity:113519] H2O [endoplasmic reticulum lumen]
literatureReference[LiteratureReference:198444] Genetic basis of glycogen storage disease type 1a: Prevalent mutations at the glucose-6-phosphatase locus
[LiteratureReference:3266567] The catalytic center of glucose-6-phosphatase. HIS176 is the nucleophile forming the phosphohistidine-enzyme intermediate during catalysis
[LiteratureReference:3274528] Mutations in the glucose-6-phosphatase gene that cause glycogen storage disease type 1a
[LiteratureReference:3274546] Mutations in the glucose-6-phosphatase-alpha (G6PC) gene that cause type Ia glycogen storage disease
modified[InstanceEdit:76579] D'Eustachio, P, 2003-10-11 14:30:00
[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:113781] Schmidt, EE, 2004-06-22 05:13:42
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:198480] D'Eustachio, P, 2007-06-22 14:17:01
[InstanceEdit:376846] D'Eustachio, P, 2008-09-08 20:57:14
[InstanceEdit:376865] D'Eustachio, P, 2008-09-09 21:35:27
[InstanceEdit:376871] D'Eustachio, P, 2008-09-10 19:02:07
[InstanceEdit:981598] Jassal, Bijay, 2010-10-25
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:3266568] D'Eustachio, P, 2013-04-10
[InstanceEdit:3274539] D'Eustachio, P, 2013-04-11
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9815667] D'Eustachio, Peter, 2022-08-25
[InstanceEdit:9815861] D'Eustachio, Peter, 2022-08-29
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9933541] Stephan, Ralf, 2025-01-02
nameG6PC hydrolyzes G6P to Glc and Pi (liver)
alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC - liver)
output[SimpleEntity:113551] Pi [endoplasmic reticulum lumen]
[SimpleEntity:113780] Glc [endoplasmic reticulum lumen]
precedingEvent
releaseDate2004-07-06
reviewed[InstanceEdit:376870] Harris, RA, 2008-09-10 18:47:12
[InstanceEdit:9815859] Hill, David P, 2022-08-29
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9815860] D'Eustachio, Peter, 2022-08-29
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359115] R-HSA-71825.6
summation[Summation:71789] Glucose-6-phosphatase (G6PC) associated with the inner face ...
(hasEvent)[Pathway:70263] Gluconeogenesis [Homo sapiens]
(inferredFrom)[Reaction:353058] glucose 6-phosphate + H2O => glucose + phosphate [Gallus gallus]
(normalReaction)[FailedReaction:3274540] Defective G6PC does not hydrolyze glucose 6-phosphate [Homo sapiens]
(precedingEvent)[BlackBoxEvent:198458] Efflux of Glc from the endoplasmic reticulum [Homo sapiens]
(updatedInstance)[_UpdateTracker:9787247] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v46:[modifyText]
[_UpdateTracker:9787427] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v45:[add_removeLiteratureReference, modifyText]
[_UpdateTracker:9790075] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v35:[addLiteratureReference, modifyText]
[_UpdateTracker:9791758] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v26:[modifyText]
[_UpdateTracker:9792259] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v22:[addLiteratureReference, modifyText]
[_UpdateTracker:9846823] Update Tracker - [Reaction:71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - v83:[modifyText]
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