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Details on Person PFKFKB dimer phosphorylates Fru(6)P

Class:Id	Reaction:71802
_displayName	PFKFKB dimer phosphorylates Fru(6)P
_doRelease	TRUE
_timestamp	2025-02-27 16:54:12
catalystActivity	[CatalystActivity:163768] 6-phosphofructo-2-kinase activity of PFKFB dimers [cytosol]
catalystActivityReference	[CatalystActivityReference:9643768] 6-phosphofructo-2-kinase activity of PFKFB dimers [cytosol] Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9933528] RHEA:15654
goBiologicalProcess	[GO_BiologicalProcess:24888] positive regulation of glycolytic process
input	[SimpleEntity:29512] Fru(6)P [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:200059] Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase [LiteratureReference:200057] Expression of human placental-type 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase in various cells and cell lines [LiteratureReference:199999] The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate [LiteratureReference:200012] Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene [LiteratureReference:450654] Hormonal regulation of hepatic gluconeogenesis and glycolysis [LiteratureReference:70163] 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme
modified	[InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:163728] Gopinathrao, G, 2005-05-06 17:09:17 [InstanceEdit:164203] Gopinathrao, G, 2005-05-12 21:32:40 [InstanceEdit:164238] Gopinathrao, G, 2005-05-13 01:40:30 [InstanceEdit:166004] Gopinathrao, G, 2005-08-12 11:14:59 [InstanceEdit:200032] D'Eustachio, P, 2007-07-13 20:48:01 [InstanceEdit:450636] D'Eustachio, P, 2009-12-16 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8982493] D'Eustachio, Peter, 2017-03-17 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9933517] Stephan, Ralf, 2025-01-01 [InstanceEdit:9939469] Stephan, Ralf, 2025-02-27
name	PFKFKB dimer phosphorylates Fru(6)P D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP Fructose 6-phosphate and ATP react to form fructose 2,6-bisphosphate and ADP
output	[SimpleEntity:30533] D-Fructose 2,6-bisphosphate [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:70471] GPI dimer isomerizes G6P [Homo sapiens] [Reaction:70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P [Homo sapiens] [Reaction:5696021] ADPGK:Mg2+ phosphorylates Glc to G6P [Homo sapiens] [Reaction:163773] PKA tetramer:cAMP phosphorylates PF2K-Pase [Homo sapiens] [Reaction:111925] cAMP induces dissociation of inactive PKA tetramers [Homo sapiens] [Reaction:163750] PP2A complex dephosphorylates pPFKFB1 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[PositiveRegulation:163759] Positive regulation by 'D-Fructose 2,6-bisphosphate [cytosol]'
releaseDate	2004-07-06
reviewed	[InstanceEdit:9939470] Matthews, Lisa, 2025-02-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359089] R-HSA-71802.7
structureModified	[InstanceEdit:9933517] Stephan, Ralf, 2025-01-01
summation	[Summation:178497] The 6-phosphofructo-2-kinase activity of cytosolic PFKFB (6-...
(hasEvent)	[Pathway:9634600] Regulation of glycolysis by fructose 2,6-bisphosphate metabolism [Homo sapiens]
(replacementInstances)	[_Deleted:450681] Deletion of instance: 70162
(updatedInstance)	[_UpdateTracker:9790526] Update Tracker - [Reaction:71802] D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP - v33:[removeRegulator] [_UpdateTracker:9790841] Update Tracker - [Reaction:71802] D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP - v32:[addLiteratureReference, modifyText] [_UpdateTracker:9792215] Update Tracker - [Reaction:71802] D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP - v22:[addLiteratureReference] [_UpdateTracker:9939687] Update Tracker - [Reaction:71802] PFKFKB dimer phosphorylates Fru(6)P - v92:[removeOutput]
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