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Details on Person MDH2 dimer reduces OA to MAL

Class:IdReaction:71783
_displayNameMDH2 dimer reduces OA to MAL
_doReleaseFALSE
_timestamp2025-08-25 13:30:46
catalystActivity[CatalystActivity:70978] L-malate dehydrogenase (NAD+) activity of MDH2 dimer [mitochondrial matrix]
catalystActivityReference[CatalystActivityReference:9643763] L-malate dehydrogenase activity of MDH2 dimer [mitochondrial matrix] An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates
compartment[Compartment:5460] mitochondrial matrix
input[SimpleEntity:113587] OA [mitochondrial matrix]
[SimpleEntity:29362] NADH [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
literatureReference[LiteratureReference:451039] An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates
[LiteratureReference:198468] Aggregation states of mitochondrial malate dehydrogenase
[LiteratureReference:9953011] Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells
modified[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:113845] D'Eustachio, P, 2004-06-23 11:10:00
[InstanceEdit:198480] D'Eustachio, P, 2007-06-22 14:17:01
[InstanceEdit:372822] D'Eustachio, P, 2008-07-03 22:07:04
[InstanceEdit:372849] D'Eustachio, P, 2008-07-07 20:55:07
[InstanceEdit:376846] D'Eustachio, P, 2008-09-08 20:57:14
[InstanceEdit:376865] D'Eustachio, P, 2008-09-09 21:35:27
[InstanceEdit:376871] D'Eustachio, P, 2008-09-10 19:02:07
[InstanceEdit:451044] D'Eustachio, P, 2009-12-26
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9815308] D'Eustachio, Peter, 2022-08-16
[InstanceEdit:9815705] D'Eustachio, Peter, 2022-08-25
[InstanceEdit:9815858] D'Eustachio, Peter, 2022-08-29
[InstanceEdit:9815861] D'Eustachio, Peter, 2022-08-29
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9854222] Stephan, Ralf, 2023-11-23
[InstanceEdit:9859508] Stephan, Ralf, 2024-01-20
[InstanceEdit:9953016] Stephan, Ralf, 2025-05-28
[InstanceEdit:9953017] Stephan, Ralf, 2025-05-28
[InstanceEdit:9956893] Stephan, Ralf, 2025-06-16
[InstanceEdit:9964568] Stephan, Ralf, 2025-08-25
nameMDH2 dimer reduces OA to MAL
H(+) + NADH + oxaloacetate => (S)-malate + NAD(+)
negativePrecedingEvent[NegativePrecedingEvent:9953018] Futile Cycle: MDH2 dimer dehydrogenates MAL
output[SimpleEntity:113544] MAL [mitochondrial matrix]
[SimpleEntity:113526] NAD+ [mitochondrial matrix]
precedingEvent
releaseDate2007-09-04
reverseReaction
reviewed[InstanceEdit:376870] Harris, RA, 2008-09-10 18:47:12
[InstanceEdit:9815859] Hill, David P, 2022-08-29
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
[InstanceEdit:9815860] D'Eustachio, Peter, 2022-08-29
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358928] R-HSA-71783.6
summation[Summation:198465] Mitochondrial malate dehydrogenase (MDH2) catalyzes the hydr...
(hasEvent)[Pathway:9856872] Malate-aspartate shuttle [Homo sapiens]
(updatedInstance)[_UpdateTracker:9790995] Update Tracker - [Reaction:71783] Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ - v32:[add_removeLiteratureReference, modifyText]
[_UpdateTracker:9791778] Update Tracker - [Reaction:71783] Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ - v26:[modifyText]
[_UpdateTracker:9846847] Update Tracker - [Reaction:71783] MDH2 reduces OA to MAL - v83:[modifyText]
[_UpdateTracker:9847054] Update Tracker - [Reaction:71783] MDH2 reduces OA to MAL - v82:[addLiteratureReference, modifyText]
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