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Details on Person SUCLG1/G2 cleaves succinyl-CoA

Class:Id	Reaction:71775
_displayName	SUCLG1/G2 cleaves succinyl-CoA
_doRelease	TRUE
_timestamp	2024-04-24 07:30:22
catalystActivity	[CatalystActivity:71774] succinate-CoA ligase (GDP-forming) activity of SUCLG1:SUCLG2 [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643311] succinate-CoA ligase (GDP-forming) activity of SUCLG1:SUCLG2 [mitochondrial matrix] Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletion
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9854182] RHEA:22122
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
input	[SimpleEntity:113525] GDP [mitochondrial matrix] [SimpleEntity:113548] Pi [mitochondrial matrix] [SimpleEntity:70958] SUCC-CoA [mitochondrial matrix]
internalReviewed	[InstanceEdit:9856153] D'Eustachio, Peter, 2023-12-12
literatureReference	[LiteratureReference:156639] Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemia [LiteratureReference:156645] Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes [LiteratureReference:156641] Characterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit. [LiteratureReference:156646] Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues [LiteratureReference:450989] Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletion [LiteratureReference:156637] Guanosine triphosphate, the primary product of phosphorylation coupled to the breakdown of succinyl coenzyme A [LiteratureReference:9853989] SUCLG1 mutations and mitochondrial encephalomyopathy: a case study and review of the literature
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:113783] Schmidt, EE, 2004-06-22 05:26:36 [InstanceEdit:156626] D'Eustachio, P, 2004-12-07 23:21:00 [InstanceEdit:156648] D'Eustachio, P, 2004-12-08 16:01:22 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:203945] Gopinathrao, G, 2007-11-19 17:27:54 [InstanceEdit:450991] D'Eustachio, P, 2009-12-24 [InstanceEdit:451044] D'Eustachio, P, 2009-12-26 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9853494] Stephan, Ralf, 2023-11-16 [InstanceEdit:9853997] Stephan, Ralf, 2023-11-22 [InstanceEdit:9854201] Stephan, Ralf, 2023-11-23 [InstanceEdit:9856154] Stephan, Ralf, 2023-12-12 [InstanceEdit:9861237] D'Eustachio, Peter, 2024-02-15 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24
name	SUCLG1/G2 cleaves succinyl-CoA GDP + phosphate + succinyl-CoA => CoA + GTP + succinate
negativePrecedingEvent	[NegativePrecedingEvent:9908914] Futile Cycle: DLST transfers succinyl to CoA
output	[SimpleEntity:113573] GTP [mitochondrial matrix] [SimpleEntity:113536] SUCCA [mitochondrial matrix] [SimpleEntity:29374] CoA-SH [mitochondrial matrix]
precedingEvent	[Reaction:71401] OGDH dimer decarboxylates 2-OG [Homo sapiens] [Reaction:70967] IDH3 complex decarboxylates isocitrate [Homo sapiens] [Reaction:9853499] DLD dimer dehydrogenates dihydrolipoyl [Homo sapiens] [Reaction:450984] IDH2 dimer decarboxylates isocitrate [Homo sapiens] [Reaction:70979] MDH2 dimer dehydrogenates MAL [Homo sapiens] [Reaction:450971] NNT dimer transfers proton from NADPH to NAD+ [Homo sapiens] [Reaction:71010] MUT isomerises L-MM-CoA to SUCC-CoA [Homo sapiens] [Reaction:71020] D-methylmalonyl-CoA <=> L-methylmalonyl-CoA [Homo sapiens] [Reaction:3159259] MMAA:MUT binds AdoCbl [Homo sapiens]
releaseDate	2004-07-06
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361541] R-HSA-71775.6
summation	[Summation:9853992] Mitochondrial succinate CoA ligase (GDP-forming) catalyzes t...
(hasEvent)	[Pathway:71403] Citric acid cycle (TCA cycle) [Homo sapiens]
(precedingEvent)	[Reaction:70994] SDH complex dehydrogenates succinate [Homo sapiens] [Reaction:163213] Transfer of electrons through the succinate dehydrogenase complex [Homo sapiens] [NegativePrecedingEvent:9908915] Futile Cycle: SUCLG1/G2 cleaves succinyl-CoA
(updatedInstance)	[_UpdateTracker:9791131] Update Tracker - [Reaction:71775] GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA - v32:[addLiteratureReference, modifyText] [_UpdateTracker:9864164] Update Tracker - [Reaction:71775] SUCLG1/G2 cleaves succinyl-CoA - v88:[addLiteratureReference, add_removeSummation]
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