Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person PPA1 hydrolyzes pyrophosphate to orthophosphate

Class:Id	Reaction:71732
_displayName	PPA1 hydrolyzes pyrophosphate to orthophosphate
_doRelease	TRUE
_timestamp	2024-08-27 15:00:47
catalystActivity	[CatalystActivity:71731] inorganic diphosphate phosphatase activity of PPA1 dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643920] inorganic diphosphatase activity of PPA1 dimer [cytosol] Studies on human erythrocyte inorganic pyrophosphatase
compartment	[Compartment:70101] cytosol
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:111294] PPi [cytosol]
literatureReference	[LiteratureReference:71727] Studies on human erythrocyte inorganic pyrophosphatase [LiteratureReference:449925] Purification and some properties of inorganic pyrophosphatase from human erythrocytes [LiteratureReference:449920] Purification and kinetic properties of human erythrocyte Mg2+-dependent inorganic pyrophosphatase
modified	[InstanceEdit:74269] D'Eustachio, P, 2003-07-17 15:30:00 [InstanceEdit:74382] D'Eustachio, P, 2003-07-18 16:30:00 [InstanceEdit:75131] D'Eustachio, P, 2003-08-26 15:20:00 [InstanceEdit:75139] D'Eustachio, P, 0000-00-00 00:00:00 [InstanceEdit:76541] D'Eustachio, P, 2003-10-09 12:23:00 [InstanceEdit:111611] D'Eustachio, P, 2004-02-23 15:45:00 [InstanceEdit:164593] D'Eustachio, P, 2005-06-02 15:10:56 [InstanceEdit:176534] D'Eustachio, P, 2006-03-08 20:43:01 [InstanceEdit:449935] D'Eustachio, P, 2009-12-09 [InstanceEdit:453149] D'Eustachio, P, 2010-01-18 [InstanceEdit:453149] D'Eustachio, P, 2010-01-18 [InstanceEdit:453149] D'Eustachio, P, 2010-01-18 [InstanceEdit:500263] D'Eustachio, P, 2010-02-01 [InstanceEdit:500750] D'Eustachio, P, 2010-02-04 [InstanceEdit:500756] D'Eustachio, P, 2010-02-04 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9731239] D'Eustachio, Peter, 2021-05-18 [InstanceEdit:9731615] D'Eustachio, Peter, 2021-05-21 [InstanceEdit:9731633] D'Eustachio, Peter, 2021-05-21 [InstanceEdit:9736302] D'Eustachio, Peter, 2021-07-06 [InstanceEdit:9736401] D'Eustachio, Peter, 2021-07-09 [InstanceEdit:9748643] D'Eustachio, Peter, 2021-07-23 [InstanceEdit:9751177] D'Eustachio, Peter, 2021-08-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9912893] D'Eustachio, Peter, 2024-06-10 [InstanceEdit:9919329] Matthews, Lisa, 2024-08-27
name	PPA1 hydrolyzes pyrophosphate to orthophosphate pyrophosphate + H2O => 2 orthophosphate [cytosolic]
output	[SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:70599] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] [Homo sapiens] [Reaction:5691507] ASPA deacetylates NAASP to acetate and L-aspartate [Homo sapiens] [Reaction:71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] [Homo sapiens] [Reaction:71691] acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] [Homo sapiens] [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA [Homo sapiens] [Reaction:70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Homo sapiens] [Reaction:70581] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] [Homo sapiens] [Reaction:70286] UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose [Homo sapiens] [Reaction:71590] glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] [Homo sapiens] [Reaction:9638127] PGM1:Mg2+ isomerises G6P to G1P [Homo sapiens] [Reaction:74213] APRT catalyzes the conversion of adenine to AMP [Homo sapiens] [Reaction:74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP [Homo sapiens] [Reaction:174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS [Homo sapiens] [Reaction:427555] SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol [Homo sapiens] [Reaction:9941470] SLC26A11 imports SO4(2-) and H+ into cytosol [Homo sapiens] [Reaction:2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP [Homo sapiens] [Reaction:2395818] NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP [Homo sapiens] [Reaction:9731228] NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP [Homo sapiens] [Reaction:9731613] NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP [Homo sapiens] [Reaction:9731632] NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP [Homo sapiens] [Reaction:9731590] NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP [Homo sapiens] [Reaction:73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate [Homo sapiens] [Reaction:111215] PRPS1 dimer pyrophosphorylates R5P using dATP [Homo sapiens] [Reaction:73580] PRPS dimers pyrophosphorylate R5P using ATP [Homo sapiens] [Reaction:111289] Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer [Homo sapiens] [Reaction:73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP [Homo sapiens] [Reaction:73569] DHODH:FMN oxidises (S)-DHO to orotate [Homo sapiens] [Reaction:111215] PRPS1 dimer pyrophosphorylates R5P using dATP [Homo sapiens] [Reaction:73580] PRPS dimers pyrophosphorylate R5P using ATP [Homo sapiens] [Reaction:73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate [Homo sapiens] [Reaction:73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] [Homo sapiens]
regulatedBy	[Requirement:449940] Requirement by 'Mg2+ [cytosol]'
regulationReference	[RegulationReference:9641612] Requirement by 'Mg2+ [cytosol]' Purification and kinetic properties of human erythrocyte Mg2+-dependent inorganic pyrophosphatase
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:449926] D'Eustachio, P, 2009-12-09
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361027] R-HSA-71732.8
summation	[Summation:179126] Cytosolic PPA1 (pyrophosphatase (inorganic) 1) catalyzes the...
(hasEvent)	[Pathway:71737] Pyrophosphate hydrolysis [Homo sapiens] [Pathway:379716] Cytosolic tRNA aminoacylation [Homo sapiens]
(inferredFrom)	[Reaction:1113133] pyrophosphate + H2O => 2 orthophosphate [cytosolic] [Oryza sativa]
(orthologousEvent)	[Reaction:1113133] pyrophosphate + H2O => 2 orthophosphate [cytosolic] [Oryza sativa]
(updatedInstance)	[_UpdateTracker:9791012] Update Tracker - [Reaction:71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - v32:[addLiteratureReference, addRegulator, modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by PPA1 hydrolyzes pyrophosphate to orthophosphate (71732)