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Details on Person glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

Class:Id	Reaction:71682
_displayName	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
_doRelease	TRUE
_timestamp	2025-12-04 01:21:46
authored	[InstanceEdit:111698] D'Eustachio, P, 2004-03-17 17:27:00
catalystActivity	[CatalystActivity:71681] glutathione-disulfide reductase (NADPH) activity of GSR-2:FAD dimer [cytosol]
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9975904] RHEA:11742
edited	[InstanceEdit:111698] D'Eustachio, P, 2004-03-17 17:27:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
input	[SimpleEntity:111745] GSSG [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:200187] Familial deficiency of glutathione reductase in human blood cells [LiteratureReference:3779352] PURIFICATION AND PROPERTIES OF GLUTATHIONE REDUCTASE OF HUMAN ERYTHROCYTES
modified	[InstanceEdit:111698] D'Eustachio, P, 2004-03-17 17:27:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:198855] D'Eustachio, P, 2007-07-05 13:28:49 [InstanceEdit:200252] D'Eustachio, P, 2007-07-16 20:10:20 [InstanceEdit:464977] D'Eustachio, P, 2010-01-24 [InstanceEdit:499929] D'Eustachio, P, 2010-01-29 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:3343748] May, B, 2013-05-12 [InstanceEdit:3779419] May, B, 2013-06-27 [InstanceEdit:8855929] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975916] D'Eustachio, Peter, 2025-12-04
name	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ glutathione disulfide + NADPH + H(+) => 2 glutathione + NADP(+)
output	[SimpleEntity:29450] GSH [cytosol] [SimpleEntity:29450] GSH [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:71299] PGD decarboxylates 6-phospho-D-gluconate [Homo sapiens] [Reaction:71296] PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate [Homo sapiens] [Reaction:70377] G6PD multimers dehydrogenate G6P [Homo sapiens] [Reaction:70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P [Homo sapiens] [Reaction:70475] GPI dimer isomerizes Fru(6)P to G6P [Homo sapiens] [Reaction:111746] glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) [Homo sapiens] [Reaction:198813] GSTO dimers reduce DeHA to AscH- [Homo sapiens] [Reaction:198818] SLC2A1,3 transports DeHA from extracellular region to cytosol [Homo sapiens]
releaseDate	2004-07-06
releaseStatus	UPDATED
reviewed	[InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358885] R-HSA-71682.5
summation	[Summation:499935] Cytosolic glutathione reductase catalyzes the reaction of gl...
(hasEvent)	[Pathway:499943] Interconversion of nucleotide di- and triphosphates [Homo sapiens] [Pathway:3299685] Detoxification of Reactive Oxygen Species [Homo sapiens] [Pathway:5628897] TP53 Regulates Metabolic Genes [Homo sapiens]
(precedingEvent)	[Reaction:71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787201] Update Tracker - [Reaction:71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - v46:[addLiteratureReference, modifyText] [_UpdateTracker:9791058] Update Tracker - [Reaction:71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - v32:[add_removeSummation] [_UpdateTracker:9792257] Update Tracker - [Reaction:71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - v22:[addLiteratureReference]
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