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Details on Person GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O

Class:Id	Reaction:71676
_displayName	GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O
_doRelease	TRUE
_timestamp	2021-01-29 16:52:45
authored	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
catalystActivity	[CatalystActivity:71675] glutathione peroxidase activity of GPX1 tetramer [cytosol]
compartment	[Compartment:70101] cytosol
edited	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:176862] D'Eustachio, P, 2006-03-15 17:27:26
input	[SimpleEntity:29450] GSH [cytosol] [SimpleEntity:29450] GSH [cytosol] [SimpleEntity:29408] H2O2 [cytosol]
literatureReference	[LiteratureReference:200035] Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI [LiteratureReference:3323072] Purification and properties of human erythrocyte glutathione peroxidase [LiteratureReference:3323004] Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cells [LiteratureReference:3323017] Glutathione peroxidase protein. Absence in selenium deficiency states and correlation with enzymatic activity
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:176862] D'Eustachio, P, 2006-03-15 17:27:26 [InstanceEdit:200032] D'Eustachio, P, 2007-07-13 20:48:01 [InstanceEdit:389952] Jassal, Bijay, 2009-01-21 [InstanceEdit:3323087] May, B, 2013-05-09 [InstanceEdit:3343748] May, B, 2013-05-12 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9713667] D'Eustachio, Peter, 2021-01-29 [InstanceEdit:9713668] D'Eustachio, Peter, 2021-01-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
output	[SimpleEntity:111745] GSSG [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ [Homo sapiens] [Reaction:71299] PGD decarboxylates 6-phospho-D-gluconate [Homo sapiens] [Reaction:70377] G6PD multimers dehydrogenate G6P [Homo sapiens] [Reaction:111746] glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) [Homo sapiens] [Reaction:198813] GSTO dimers reduce DeHA to AscH- [Homo sapiens] [Reaction:3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) [Homo sapiens] [Reaction:3299753] CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 [Homo sapiens] [Reaction:74247] XDH oxidizes hypoxanthine to form xanthine [Homo sapiens] [Reaction:74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose [Homo sapiens] [FailedReaction:9734274] Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP [Homo sapiens] [Reaction:74258] XDH oxidizes xanthine to form urate [Homo sapiens] [Reaction:74255] Guanine + H2O => Xanthine + NH4+ [Homo sapiens] [Reaction:74247] XDH oxidizes hypoxanthine to form xanthine [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358590] R-HSA-71676.4
summation	[Summation:178256] Cytosolic glutathione peroxidase (GPX1) tetramer catalyzes t...
(hasEvent)	[Pathway:3299685] Detoxification of Reactive Oxygen Species [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787327] Update Tracker - [Reaction:71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O - v45:[addLiteratureReference] [_UpdateTracker:9790103] Update Tracker - [Reaction:71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O - v35:[modifyText] [_UpdateTracker:9791600] Update Tracker - [Reaction:71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O - v28:[addOutput] [_UpdateTracker:9792228] Update Tracker - [Reaction:71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O - v22:[addLiteratureReference]
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