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Details on Person Pyruvate kinase dephosphorylates PEP to PYR
Class:Id Reaction:71670 _displayName Pyruvate kinase dephosphorylates PEP to PYR _doRelease TRUE _timestamp 2025-08-27 18:57:15 authored [InstanceEdit:141518] D'Eustachio, P, 2004-09-21 15:25:22 catalystActivity [CatalystActivity:71669] pyruvate kinase activity of pyruvate kinase tetramer [cytosol] catalystActivityReference [CatalystActivityReference:9643408] pyruvate kinase activity of pyruvate kinase tetramer [cytosol] Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis compartment [Compartment:70101] cytosol crossReference [DatabaseIdentifier:9861809] RHEA:18159 input [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29492] PEP [cytosol] [SimpleEntity:70106] H+ [cytosol] literatureReference [LiteratureReference:450664] Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis [LiteratureReference:450661] cDNA cloning of human R-type pyruvate kinase and identification of a single amino acid substitution (Thr384----Met) affecting enzymatic stability in a pyruvate kinase variant (PK Tokyo) associated with hereditary hemolytic anemia [LiteratureReference:450640] Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription [LiteratureReference:141473] Isolation and characterization of the human pyruvate kinase M gene [LiteratureReference:141558] Human liver type pyruvate kinase: complete amino acid sequence and the expression in mammalian cells [LiteratureReference:450635] Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia [LiteratureReference:450637] Red cell pyruvate kinase deficiency: molecular and clinical aspects [LiteratureReference:9861717] Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis modified [InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00 [InstanceEdit:141590] D'Eustachio, P, 2004-09-21 16:29:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:179499] D'Eustachio, P, 2006-05-04 21:45:03 [InstanceEdit:179500] D'Eustachio, P, 2006-05-04 21:47:47 [InstanceEdit:179501] D'Eustachio, P, 2006-05-04 21:47:49 [InstanceEdit:450636] D'Eustachio, P, 2009-12-16 [InstanceEdit:450684] D'Eustachio, P, 2009-12-16 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9670153] D'Eustachio, Peter, 2019-12-04 [InstanceEdit:9674775] D'Eustachio, Peter, 2020-01-23 [InstanceEdit:9677161] D'Eustachio, Peter, 2020-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9856745] D'Eustachio, Peter, 2023-12-22 [InstanceEdit:9861887] Stephan, Ralf, 2024-02-21 [InstanceEdit:9862185] Stephan, Ralf, 2024-02-23 [InstanceEdit:9862190] Stephan, Ralf, 2024-02-23 [InstanceEdit:9965317] D'Eustachio, Peter, 2025-08-27 name Pyruvate kinase dephosphorylates PEP to PYR output [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29398] PYR [cytosol] precedingEvent
previousReviewStatus [ReviewStatus:9821384] two stars regulatedBy [NegativeRegulation:71661] Negative regulation by 'ATP [nucleoplasm]' [PositiveRegulation:71662] Positive regulation by 'F1,6PP [cytosol]' [NegativeRegulation:71663] Negative regulation by 'Ac-CoA [cytosol]' [NegativeRegulation:71664] Negative regulation by 'cAMP [cytosol]' [NegativeRegulation:9861890] Negative regulation by 'PolyUb-PKM-1 [cytosol]' regulationReference [RegulationReference:9861891] Negative regulation by 'PolyUb-PKM-1 [cytosol]' Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis releaseDate 2004-07-06 reviewed [InstanceEdit:9862191] Hill, David P, 2024-02-23 reviewStatus [ReviewStatus:9821382] five stars revised [InstanceEdit:450685] D'Eustachio, P, 2009-12-16 species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:359343] R-HSA-71670.9 structureModified [InstanceEdit:9861887] Stephan, Ralf, 2024-02-21 summation [Summation:141540] Cytosolic pyruvate kinase catalyzes the transfer of a high-e... (hasEvent) [Pathway:70171] Glycolysis [Homo sapiens] [Pathway:70268] Pyruvate metabolism [Homo sapiens] (precedingEvent) [Reaction:71849] LDH tetramer reduces PYR to LACT [Homo sapiens] [Reaction:372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix [Homo sapiens] [Reaction:9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Homo sapiens] [Reaction:9861595] Cytosolic H2O2 decarboxylates PYR to acetate [Homo sapiens] (replacementInstances) [_Deleted:450677] Deletion of instance: 70102 [_Deleted:450678] Deletion of instance: 70100 (updatedInstance) [_UpdateTracker:9777291] Update Tracker - [Reaction:71670] phosphoenolpyruvate + ADP => pyruvate + ATP - v72:[addInput] [_UpdateTracker:9791199] Update Tracker - [Reaction:71670] phosphoenolpyruvate + ADP => pyruvate + ATP - v32:[addLiteratureReference, addRegulator, modifyText] [_UpdateTracker:9864338] Update Tracker - [Reaction:71670] PKM dephosphorylates PEP to PYR - v88:[addLiteratureReference, addRegulator]
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