Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP

Class:IdReaction:71541
_displayNameglycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP
_doReleaseTRUE
_timestamp2025-06-02 17:50:02
catalystActivity[CatalystActivity:71521] phosphorylase kinase activity of phosphorylase kinase complex (PHKM) [cytosol]
catalystActivityReference[CatalystActivityReference:9643104] phosphorylase kinase activity of phosphorylase kinase complex (PHKM) [cytosol] Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases
compartment[Compartment:70101] cytosol
crossReference[DatabaseIdentifier:9857128] RHEA:17990
input[Complex:71538] PYGM dimer, b form [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
internalReviewed[InstanceEdit:9939460] D'Eustachio, Peter, 2025-02-27
literatureReference[LiteratureReference:453281] Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure
[LiteratureReference:453283] Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases
[LiteratureReference:453328] Correlation between subunit interactions and enzymatic activity of phosphorylase a. Method for determining equilibrium constants from initial rate measurements
[LiteratureReference:453354] Enzymic conversion of phosphorylase a to phosphorylase b
modified[InstanceEdit:73440] D'Eustachio, P, 2003-06-16 00:00:00
[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:199720] D'Eustachio, P, 2007-07-11 20:28:53
[InstanceEdit:453123] D'Eustachio, P, 2010-01-18
[InstanceEdit:453290] D'Eustachio, P, 2010-01-20
[InstanceEdit:453352] D'Eustachio, P, 2010-01-21
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9931474] D'Eustachio, Peter, 2024-12-11
[InstanceEdit:9931476] D'Eustachio, Peter, 2024-12-11
[InstanceEdit:9939603] Matthews, Lisa, 2025-03-04
[InstanceEdit:9953438] D'Eustachio, Peter, 2025-06-02
nameglycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP
L-seryl-(protein) + ATP => O-phospho-L-seryl-(protein) + ADP + H(+)
output[Complex:71513] PYGM dimer a form [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
regulatedBy[PositiveRegulation:71542] Positive regulation by 'Ca2+ [cytosol]'
releaseDate2004-07-06
reviewed[InstanceEdit:9953436] Hill, David P, 2025-06-02
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:453329] D'Eustachio, P, 2010-01-21
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359204] R-HSA-71541.7
structureModified[InstanceEdit:9931474] D'Eustachio, Peter, 2024-12-11
summation[Summation:178818] The cytosolic phosphorylase kinase complex catalyzes the pho...
(hasEvent)[Pathway:70221] Glycogen breakdown (glycogenolysis) [Homo sapiens]
(inferredFrom)[Reaction:453337] glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP [Homo sapiens]
(precedingEvent)[Reaction:71515] glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] [Homo sapiens]
[Reaction:453358] poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] [Homo sapiens]
(replacementInstances)[_Deleted:453301] Deletion of instance: 70172
(updatedInstance)[_UpdateTracker:9791094] Update Tracker - [Reaction:71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - v32:[add_removeLiteratureReference, modifyText]
[_UpdateTracker:9792226] Update Tracker - [Reaction:71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - v22:[addLiteratureReference]
[_UpdateTracker:9939708] Update Tracker - [Reaction:71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - v92:[removeOutput]
[Change default viewing format]
No pathways have been reviewed or authored by glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (71541)
Follow Reactome