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Details on Person Aldolase tetramers convert GA3P and DHAP to F1,6PP

Class:Id	Reaction:71495
_displayName	Aldolase tetramers convert GA3P and DHAP to F1,6PP
_doRelease	TRUE
_timestamp	2025-01-01 11:03:53
catalystActivity	[CatalystActivity:71494] fructose-bisphosphate aldolase activity of aldolase tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643497] fructose-bisphosphate aldolase activity of aldolase tetramer [cytosol] Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9933522] RHEA:14731
input	[SimpleEntity:75970] DHAP [cytosol] [SimpleEntity:29578] GA3P [cytosol]
literatureReference	[LiteratureReference:141482] Diverse mutations in the aldolase B gene that underlie the prevalence of hereditary fructose intolerance [LiteratureReference:141571] The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:179507] D'Eustachio, P, 2006-05-05 15:53:26 [InstanceEdit:198480] D'Eustachio, P, 2007-06-22 14:17:01 [InstanceEdit:376871] D'Eustachio, P, 2008-09-10 19:02:07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9815667] D'Eustachio, Peter, 2022-08-25 [InstanceEdit:9815861] D'Eustachio, Peter, 2022-08-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9933517] Stephan, Ralf, 2025-01-01
name	Aldolase tetramers convert GA3P and DHAP to F1,6PP D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate
output	[SimpleEntity:30014] F1,6PP [cytosol]
precedingEvent	[Reaction:70482] GAPDH tetramers reduce 1,3BPG to GA3P [Homo sapiens] [Reaction:70486] PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG [Homo sapiens] [Reaction:70481] TPI1 dimer isomerizes GA3P to DHAP [Homo sapiens] [Reaction:70482] GAPDH tetramers reduce 1,3BPG to GA3P [Homo sapiens]
releaseDate	2004-07-06
reverseReaction	[Reaction:71496] Aldolase tetramer cleaves F1,6PP [Homo sapiens] [Reaction:71495] Aldolase tetramers convert GA3P and DHAP to F1,6PP [Homo sapiens]
reviewed	[InstanceEdit:376870] Harris, RA, 2008-09-10 18:47:12 [InstanceEdit:9815859] Hill, David P, 2022-08-29
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9815860] D'Eustachio, Peter, 2022-08-29
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361476] R-HSA-71495.6
summation	[Summation:71449] In this freely reversible cytosolic reaction, DHAP (dihydrox...
(hasEvent)	[Pathway:70263] Gluconeogenesis [Homo sapiens]
(precedingEvent)	[Reaction:70479] FBP tetramers hydrolyze F1,6PP to Fru(6)P [Homo sapiens]
(reverseReaction)	[Reaction:71496] Aldolase tetramer cleaves F1,6PP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791725] Update Tracker - [Reaction:71495] dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate - v26:[modifyText] [_UpdateTracker:9846876] Update Tracker - [Reaction:71495] Aldolase tetramers convert GA3P and DHAP to F1,6PP - v83:[modifyText]
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