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Details on Person Cytosolic phosphofructokinase 1 catalyzes the reaction of fr...

Class:IdSummation:71462
_displayNameCytosolic phosphofructokinase 1 catalyzes the reaction of fr...
_timestamp2025-08-29 14:51:31
modified[InstanceEdit:179513] D'Eustachio, P, 2006-05-05 18:17:28
[InstanceEdit:450636] D'Eustachio, P, 2009-12-16
[InstanceEdit:9965413] D'Eustachio, Peter, 2025-08-29
textCytosolic phosphofructokinase 1 catalyzes the reaction of fructose 6-phosphate and ATP to form fructose 1,6-bisphosphate and ADP. This reaction, irreversible under physiological conditions, is the rate limiting step of glycolysis. Phosphofructokinase 1 activity is allosterically regulated by ATP, citrate, and fructose 2,6-bisphosphate.

Phosphofructokinase 1 is active as a tetramer (higher order multimers, not annotated here, may form in vivo). Two isoforms of phosphofructokinase 1 monomer, L and M, are widely expressed in human tissues; a third isoform, P, is abundant in platelets. Different tissues can contain different homotetramers or heterotetramers: L4 in liver, M4 in muscle, and all possible heterotetramers, L4, L3M, L2M2, LM3, and M4, in red blood cells, for example (Eto et al. 1994; Raben et al. 1995; Vora et al. 1980, 1987; Vora 1981). Heterotetramers and homotetramers show very similar enzymatic activities (Vora 1981); only homotetrameric forms are annotated here.

(replacementInstances)[_Deleted:9965420] Deletion of instances: 70461, 70463, 71475, 179514, 179515, 179516
(summation)[Reaction:70467] PFK tetramer phosphorylates Fru(6)P [Homo sapiens]
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