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Details on Person Mitochondrial aconitase (ACO2) reversibly converts citrate t...
| Class:Id | Summation:71415 |
|---|---|
| _displayName | Mitochondrial aconitase (ACO2) reversibly converts citrate t... |
| _timestamp | 2023-11-17 10:29:34 |
| modified | [InstanceEdit:198405] D'Eustachio, P, 2007-06-18 16:46:57 [InstanceEdit:450991] D'Eustachio, P, 2009-12-24 [InstanceEdit:451028] D'Eustachio, P, 2009-12-26 [InstanceEdit:9853615] Stephan, Ralf, 2023-11-17 |
| text | Mitochondrial aconitase (ACO2) reversibly converts citrate to isocitrate via a cis-aconitate intermediate. Mitochondrial aconitase activity has been demonstrated in diverse human tissue extracts (Slaughter et al., 1975), and a protein homologous to the well-characterized porcine enzyme has been purified from human tissues (Baldwin et al., 1991). Mutations in the ACO2 gene can lead to an infantile neurodegenerative disease (ICRD; MIM:614559) and optic atrophy (OPA9; MIM:616289) (see Guehlouz et al., 2021). |
| (summation) | [Reaction:70971] ACO2 isomerizes citrate [Homo sapiens] |
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