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Details on Person Mitochondrial citrate synthase (CS) dimer catalyzes the irre...
| Class:Id | Summation:71414 |
|---|---|
| _displayName | Mitochondrial citrate synthase (CS) dimer catalyzes the irre... |
| _timestamp | 2024-02-15 20:40:44 |
| modified | [InstanceEdit:198405] D'Eustachio, P, 2007-06-18 16:46:57 [InstanceEdit:450991] D'Eustachio, P, 2009-12-24 [InstanceEdit:9853593] Stephan, Ralf, 2023-11-17 [InstanceEdit:9855608] Stephan, Ralf, 2023-12-05 [InstanceEdit:9861208] Stephan, Ralf, 2024-02-15 [InstanceEdit:9861237] D'Eustachio, Peter, 2024-02-15 |
| text | Mitochondrial citrate synthase (CS) dimer catalyzes the irreversible reaction of acetyl-CoA, water, and oxaloacetate to form citrate and coenzyme A. This reaction is the entry point of two-carbon units into the citric acid cycle. The reaction is subject to allosteric regulation. Most of the time, CS is trimethylated on Lys-395 which attenuates its enzymatic activity (Malecki et al. 2017). The gene encoding the human enzyme has been cloned (Goldenthal et al. 1998), but the enzyme has not been characterized in detail. Its properties are inferred from those of the well-studied homologous pig enzyme (e.g., Morgunov and Srere 1998). CS dimer, malate dehydrogenase MDH2, and aconitase ACO2 form a multienzyme complex ("metabolon") that optimally channels the substrate flow between them (Fahien & Kmiotek, 1983; Wu & Minteer, 2014; Omini et al., 2021). |
| (summation) | [Reaction:70975] CS acetylates OA to citrate [Homo sapiens] |
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