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Details on Person xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate

Class:IdReaction:71335
_displayNamexylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate
_doReleaseTRUE
_timestamp2025-01-06 09:06:54
catalystActivity[CatalystActivity:71323] transketolase activity of TKT dimer [cytosol]
catalystActivityReference[CatalystActivityReference:9643773] transketolase activity of TKT dimer [cytosol] Aspartate 155 of human transketolase is essential for thiamine diphosphate-magnesium binding, and cofactor binding is required for dimer formation
compartment[Compartment:70101] cytosol
crossReference[DatabaseIdentifier:9934065] RHEA:27627
input[SimpleEntity:29790] XY5P [cytosol]
[SimpleEntity:29878] E4P [cytosol]
literatureReference[LiteratureReference:199810] Aspartate 155 of human transketolase is essential for thiamine diphosphate-magnesium binding, and cofactor binding is required for dimer formation
modified[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:163728] Gopinathrao, G, 2005-05-06 17:09:17
[InstanceEdit:199798] D'Eustachio, P, 2007-07-12 14:26:41
[InstanceEdit:469645] D'Eustachio, P, 2010-01-25
[InstanceEdit:5662845] D'Eustachio, Peter, 2015-01-13
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9934059] Stephan, Ralf, 2025-01-06
[InstanceEdit:9934068] Stephan, Ralf, 2025-01-06
namexylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate
TKT dimer transfers two-carbon ketol group onto E4P
output[SimpleEntity:29578] GA3P [cytosol]
[SimpleEntity:29512] Fru(6)P [cytosol]
precedingEvent
releaseDate2004-07-06
reverseReaction
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:469644] D'Eustachio, P, 2010-01-24
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360787] R-HSA-71335.5
summation[Summation:179338] Cytosolic transketolase (TKT) catalyzes the reaction of D-er...
(hasEvent)[Pathway:71336] Pentose phosphate pathway [Homo sapiens]
(reverseReaction)[Reaction:163751] D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate [Homo sapiens]
(updatedInstance)[_UpdateTracker:9780892] Update Tracker - [Reaction:71335] xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate - v61:[modifyText]
[_UpdateTracker:9790967] Update Tracker - [Reaction:71335] xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate - v32:[modifyText]
[_UpdateTracker:9792341] Update Tracker - [Reaction:71335] xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate - v22:[addLiteratureReference]
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