Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
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Details on Person In humans, creatine is synthesized primarily in the liver an...
| Class:Id | Summation:71290 |
|---|---|
| _displayName | In humans, creatine is synthesized primarily in the liver an... |
| _timestamp | 2007-07-18 15:18:43 |
| created | [InstanceEdit:71289] 2003-04-23 00:00:00 |
| literatureReference | [LiteratureReference:71264] Genetic disorders of carnitine metabolism and their nutritional management |
| modified | [InstanceEdit:200320] D'Eustachio, P, 2007-07-18 14:33:15 [InstanceEdit:200389] D'Eustachio, P, 2007-07-18 15:18:41 |
| text | In humans, creatine is synthesized primarily in the liver and kidney, from glycine, arginine, and S-adenosylmethionine, in a sequence of two reactions. From the liver, creatine is exported to tissues such as skeletal muscle and brain, where it undergoes phosphorylation and serves as a short-term energy store. The mechanism by which creatine leaves producer tissues is unclear, but its uptake by consumer tissues is mediated by the SLC6A8 transporter. Once formed, phosphocreatine undergoes a slow spontaneous reaction to form creatinine, which is excreted from the body. |
| (summation) | [Pathway:71288] Creatine metabolism [Homo sapiens] |
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No pathways have been reviewed or authored by In humans, creatine is synthesized primarily in the liver an... (71290)
