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Details on Person ALDH9A1 tetramer dehydrogenates TEABL to form TEABT

Class:IdReaction:71260
_displayNameALDH9A1 tetramer dehydrogenates TEABL to form TEABT
_doReleaseTRUE
_timestamp2023-11-17 17:26:50
catalystActivity[CatalystActivity:71259] 4-trimethylammoniobutyraldehyde dehydrogenase activity of ALDH9A1 tetramer [cytosol]
catalystActivityReference[CatalystActivityReference:9643469] 4-trimethylammoniobutyraldehyde dehydrogenase activity of ALDH9A1 tetramer [cytosol] Kinetic and structural analysis of human ALDH9A1
compartment[Compartment:70101] cytosol
input[SimpleEntity:31311] TEABL [cytosol]
[SimpleEntity:29360] NAD+ [cytosol]
[SimpleEntity:29356] H2O [cytosol]
literatureReference[LiteratureReference:9794602] Kinetic and structural analysis of human ALDH9A1
[LiteratureReference:71252] Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde
[LiteratureReference:71255] Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis.
modified[InstanceEdit:113752] Schmidt, EE, 2004-06-21 10:53:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:584171] D'Eustachio, P, 2010-04-11
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8953084] D'Eustachio, Peter, 2016-12-21
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9794616] D'Eustachio, Peter, 2022-07-18
[InstanceEdit:9794703] D'Eustachio, Peter, 2022-07-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9853618] D'Eustachio, Peter, 2023-11-17
nameALDH9A1 tetramer dehydrogenates TEABL to form TEABT
4-(trimethylamino)butanal + H2O + NAD(+) => 4-(trimethylamino)butanoate + 2 H(+) + NADH
gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+
output[SimpleEntity:31369] TEABT [cytosol]
[SimpleEntity:73473] NADH [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9794704] D'Eustachio, Peter, 2022-07-19
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358303] R-HSA-71260.7
summation[Summation:178802] Cytosolic 4-trimethylaminobutyraldehyde dehydrogenase (ALDH9...
(hasEvent)[Pathway:71262] Carnitine synthesis [Homo sapiens]
(precedingEvent)[Reaction:71261] BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9781553] Update Tracker - [Reaction:71260] ALDH9A1 tetramer dehydrogenates TEABL to form TEABT - v60:[modifyText]
[_UpdateTracker:9789375] Update Tracker - [Reaction:71260] ALDH9A1 tetramer dehydrogenates TEABL to form TEABT - v38:[modifyText]
[_UpdateTracker:9790762] Update Tracker - [Reaction:71260] ALDH9A1 tetramer dehydrogenates TEABL to form TEABT - v33:[addInput]
[_UpdateTracker:9847012] Update Tracker - [Reaction:71260] ALDH9A1 tetramer dehydrogenates TEABL to form TEABT - v82:[addLiteratureReference, modifyText]
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