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Details on Person SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly

Class:Id	Reaction:71249
_displayName	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly
_doRelease	TRUE
_timestamp	2023-11-17 17:26:53
catalystActivity	[CatalystActivity:71248] aldehyde-lyase activity of SHMT1 tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643735] aldehyde-lyase activity of SHMT1 tetramer [cytosol] Affinity purification and characterization of serine hydroxymethyltransferases from rat liver
compartment	[Compartment:70101] cytosol
input	[SimpleEntity:31503] HTMLYS [cytosol]
literatureReference	[LiteratureReference:9794618] Affinity purification and characterization of serine hydroxymethyltransferases from rat liver [LiteratureReference:9794628] Purification and characterization of cytosolic and mitochondrial serine hydroxymethyltransferases from rat liver [LiteratureReference:9794615] Carnitine biosynthesis in mammals [URL:9853457] https://www.researchsquare.com/article/rs-3295520/v1
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:421638] D'Eustachio, P, 2009-05-19 13:26:30 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8953084] D'Eustachio, Peter, 2016-12-21 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9794616] D'Eustachio, Peter, 2022-07-18 [InstanceEdit:9794703] D'Eustachio, Peter, 2022-07-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9853456] D'Eustachio, Peter, 2023-11-15 [InstanceEdit:9853618] D'Eustachio, Peter, 2023-11-17
name	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine => 4-(trimethylamino)butanal + glycine beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine
output	[SimpleEntity:31311] TEABL [cytosol] [SimpleEntity:29424] Gly [cytosol]
precedingEvent	[BlackBoxEvent:8949413] HTMLYS translocates from the mitochondrial matrix to the cytosol [Homo sapiens] [Reaction:71241] TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:421639] D'Eustachio, P, 2009-05-19 13:25:07 [InstanceEdit:9794704] D'Eustachio, Peter, 2022-07-19
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358232] R-HSA-71249.7
summation	[Summation:178503] Cytosolic serine hydroxymethyltransferase tetramer (SHMT1) c...
(hasEvent)	[Pathway:71262] Carnitine synthesis [Homo sapiens]
(precedingEvent)	[Reaction:71260] ALDH9A1 tetramer dehydrogenates TEABL to form TEABT [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781656] Update Tracker - [Reaction:71249] SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly - v60:[addLiteratureReference, modifyText] [_UpdateTracker:9789283] Update Tracker - [Reaction:71249] SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly - v38:[modifyText] [_UpdateTracker:9847026] Update Tracker - [Reaction:71249] SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly - v82:[add_removeLiteratureReference, modifyText] [_UpdateTracker:9864298] Update Tracker - [Reaction:71249] SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly - v88:[addLiteratureReference, modifyText]
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