Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q8K4H1 Afmid
| Class:Id | ReferenceGeneProduct:71190 |
|---|---|
| _chainChangeLog | chain:1-305 added on Fri February 6 2015 |
| _displayName | UniProt:Q8K4H1 Afmid |
| _timestamp | 2025-02-21 19:08:19 |
| chain | chain:1-305 |
| checksum | 898000A577132A52 |
| comment | FUNCTION Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.CATALYTIC ACTIVITY N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)BIOPHYSICOCHEMICAL PROPERTIES Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.SUBUNIT Homodimer.SUBCELLULAR LOCATION Predominantly cytosolic. Some fraction is nuclear.ALTERNATIVE PRODUCTS Highly expressed in liver. Expressed in kidney. Weakly or not expressed in other tissues.INDUCTION Down-regulated upon IL2-mediated activation. Transcriptional activation correlates with reduced histone acetylation.DOMAIN The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.PTM The N-terminus is blocked.DISRUPTION PHENOTYPE Mice display sclerosis of kidney glomeruli, possibly due to failures in the elimination of toxic metabolites.MISCELLANEOUS The Afmid gene shares a bidirectional promoter region with Tk1 gene.SIMILARITY Belongs to the kynurenine formamidase family. |
| description | recommendedName: fullName evidence="1"Kynurenine formamidase shortName evidence="1"KFA shortName evidence="1"KFase ecNumber evidence="1"3.5.1.9 alternativeName: fullName evidence="1"Arylformamidase alternativeName: fullName evidence="1"N-formylkynurenine formamidase shortName evidence="1"FKF |
| geneName | Afmid |
| identifier | Q8K4H1 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm Direct protein sequencing Hydrolase Nucleus Reference proteome Tryptophan catabolism |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Afmid |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | KFA_MOUSE B1AQK9 Q80XP3 Q8R1K6 |
| sequenceLength | 305 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:218180] UniProt:Q8K4H1-2 Afmid [Mus musculus] [ReferenceIsoform:411106] UniProt:Q8K4H1-1 Afmid [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:71191] kynurenine formamidase [cytosol] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8K4H1 Afmid (71190)
