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Details on Person AFMID hydrolyses NFK to L-KYN

Class:Id	Reaction:71189
_displayName	AFMID hydrolyses NFK to L-KYN
_doRelease	TRUE
_timestamp	2025-02-25 22:16:20
authored	[InstanceEdit:164915] D'Eustachio, P, 2005-07-20 13:46:37
catalystActivity	[CatalystActivity:178109] arylformamidase activity of AFMID [cytosol]
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9929638] RHEA:13010
edited	[InstanceEdit:164915] D'Eustachio, P, 2005-07-20 13:46:37
inferredFrom	[Reaction:71196] N-formylkynurenine + H2O => kynurenine + formate [mouse] [Mus musculus]
input	[SimpleEntity:33179] NFK [cytosol] [SimpleEntity:29356] H2O [cytosol]
internalReviewed	[InstanceEdit:9930750] D'Eustachio, Peter, 2024-12-05
literatureReference	[LiteratureReference:71192] Kynurenine formamidase: determination of primary structure and modeling-based prediction of tertiary structure and catalytic triad
modified	[InstanceEdit:156459] D'Eustachio, P, 2004-11-15 16:15:26 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:178110] D'Eustachio, P, 2006-04-14 23:31:00 [InstanceEdit:197283] Jassal, B, 2007-05-02 10:05:07 [InstanceEdit:198560] D'Eustachio, P, 2007-06-22 18:24:32 [InstanceEdit:200480] D'Eustachio, P, 2007-07-19 16:12:23 [InstanceEdit:1080815] D'Eustachio, P, 2010-11-27 [InstanceEdit:2247552] D'Eustachio, P, 2012-05-14 [InstanceEdit:8939588] Jassal, Bijay, 2016-09-20 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929640] D'Eustachio, Peter, 2024-11-27 [InstanceEdit:9929687] D'Eustachio, Peter, 2024-11-27 [InstanceEdit:9930749] D'Eustachio, Peter, 2024-12-06 [InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
name	AFMID hydrolyses NFK to L-KYN H2O + N-formyl-L-kynurenine => formate + H(+) + L-kynurenine N-formylkynurenine + H2O => kynurenine + formate
output	[SimpleEntity:29970] L-KYN [cytosol] [SimpleEntity:29460] HCOOH [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:71188] TDO tetramer dioxygenates L-Trp to NFK [Homo sapiens] [Reaction:352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol [Homo sapiens] [Reaction:8870352] SLC36A4 transports L-Trp from extracellular region to cytosol [Homo sapiens] [Reaction:198563] IDO1 dioxygenates L-Trp to NFK [Homo sapiens] [Reaction:352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol [Homo sapiens] [Reaction:8870352] SLC36A4 transports L-Trp from extracellular region to cytosol [Homo sapiens] [Reaction:888614] IDO2 dioxygenates L-Trp to NFK [Homo sapiens] [Reaction:352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol [Homo sapiens] [Reaction:8870352] SLC36A4 transports L-Trp from extracellular region to cytosol [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewed	[InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359647] R-HSA-71189.4
structureModified	[InstanceEdit:9929640] D'Eustachio, Peter, 2024-11-27
summation	[Summation:178964] Cytosolic arylformamidase (AFMID) catalyzes the hydrolysis o...
(hasEvent)	[Pathway:71240] Tryptophan catabolism [Homo sapiens]
(precedingEvent)	[Reaction:71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O [Homo sapiens] [Reaction:893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Homo sapiens] [Reaction:901097] PXLP-KYAT3 (CCBL2) dimer transaminates L-KYN to KYNA [Homo sapiens] [Reaction:9971629] Unknown NAT N-acetylates kynurenine [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788551] Update Tracker - [Reaction:71189] AFMID hydrolyses NFK to L-KYN - v41:[addLiteratureReference, modifyText] [_UpdateTracker:9939773] Update Tracker - [Reaction:71189] AFMID hydrolyses NFK to L-KYN - v92:[removeOutput]
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