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Details on Person FAH cleaves 4FAA

Class:IdReaction:71181
_displayNameFAH cleaves 4FAA
_doReleaseTRUE
_timestamp2024-11-22 22:11:00
authored[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity[CatalystActivity:71180] fumarylacetoacetase activity of FAH dimer [cytosol]
catalystActivityReference[CatalystActivityReference:9643990] fumarylacetoacetase activity of FAH dimer [cytosol] Characterization of the human fumarylacetoacetate hydrolase gene and identification of a missense mutation abolishing enzymatic activity
compartment[Compartment:70101] cytosol
crossReference[DatabaseIdentifier:9855287] RHEA:10245
edited[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input[SimpleEntity:31175] 4FAA [cytosol]
[SimpleEntity:29356] H2O [cytosol]
internalReviewed[InstanceEdit:9856173] D'Eustachio, Peter, 2023-12-13
literatureReference[LiteratureReference:71176] Characterization of the human fumarylacetoacetate hydrolase gene and identification of a missense mutation abolishing enzymatic activity
[LiteratureReference:9855927] Purification and properties of a diketo acid hydrolase from beef liver
[LiteratureReference:9855932] Hereditary tyrosinaemia type I: from basics to progress in treatment
[LiteratureReference:9855550] The genetic tyrosinemias
modified[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:517440] D'Eustachio, P, 2010-02-18
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:1080814] D'Eustachio, P, 2010-11-27
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8963951] Jassal, Bijay, 2017-02-14
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9855286] Stephan, Ralf, 2023-12-01
[InstanceEdit:9855935] Stephan, Ralf, 2023-12-08
[InstanceEdit:9856170] Stephan, Ralf, 2023-12-13
[InstanceEdit:9859596] Stephan, Ralf, 2024-01-22
[InstanceEdit:9929230] D'Eustachio, Peter, 2024-11-22
nameFAH cleaves 4FAA
4-fumarylacetoacetate + H2O => acetoacetate + fumarate + H(+)
fumarylacetoacetate => fumarate + acetoacetate
output[SimpleEntity:29586] FUMA [cytosol]
[SimpleEntity:29666] ACA [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9856173] D'Eustachio, Peter, 2023-12-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359982] R-HSA-71181.7
structureModified[InstanceEdit:9855286] Stephan, Ralf, 2023-12-01
summation[Summation:178797] This is the final step of tyrosine degradation. Fumarylaceto...
(hasEvent)[Pathway:8963684] Tyrosine catabolism [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777661] Update Tracker - [Reaction:71181] fumarylacetoacetate => fumarate + acetoacetate - v69:[modifyText]
[_UpdateTracker:9781010] Update Tracker - [Reaction:71181] fumarylacetoacetate => fumarate + acetoacetate - v61:[modifyText]
[_UpdateTracker:9791216] Update Tracker - [Reaction:71181] fumarylacetoacetate => fumarate + acetoacetate - v32:[addInput, modifyText]
[_UpdateTracker:9864218] Update Tracker - [Reaction:71181] FAH cleaves 4FAA - v88:[addLiteratureReference, addOutput, modifyText]
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No pathways have been reviewed or authored by FAH cleaves 4FAA (71181)
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