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Details on Person HGD dioxygenates homogentisate

Class:IdReaction:71164
_displayNameHGD dioxygenates homogentisate
_doReleaseTRUE
_timestamp2024-11-22 22:11:01
authored[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity[CatalystActivity:71084] homogentisate 1,2-dioxygenase activity of HGD hexamer [cytosol]
catalystActivityReference[CatalystActivityReference:9643129] homogentisate 1,2-dioxygenase activity of HGD hexamer [cytosol] The molecular basis of alkaptonuria
compartment[Compartment:70101] cytosol
crossReference[DatabaseIdentifier:9855289] RHEA:15450
edited[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input[SimpleEntity:30337] HGTA [cytosol]
[SimpleEntity:29368] O2 [cytosol]
internalReviewed[InstanceEdit:9856173] D'Eustachio, Peter, 2023-12-13
literatureReference[LiteratureReference:71077] Crystal structure of human homogentisate dioxygenase.
[LiteratureReference:517446] The molecular basis of alkaptonuria
[LiteratureReference:9855787] Alkaptonuria: Current Perspectives
[LiteratureReference:9855784] Steady-state kinetics and inhibition of anaerobically purified human homogentisate 1,2-dioxygenase
modified[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:517440] D'Eustachio, P, 2010-02-18
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:1080814] D'Eustachio, P, 2010-11-27
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8963951] Jassal, Bijay, 2017-02-14
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9855286] Stephan, Ralf, 2023-12-01
[InstanceEdit:9855783] Stephan, Ralf, 2023-12-07
[InstanceEdit:9856170] Stephan, Ralf, 2023-12-13
[InstanceEdit:9859596] Stephan, Ralf, 2024-01-22
[InstanceEdit:9929230] D'Eustachio, Peter, 2024-11-22
nameHGD dioxygenates homogentisate
homogentisate + O2 => 4-maleylacetoacetate + H(+)
homogentisate + O2 => maleylacetoacetate
output[SimpleEntity:31135] 4MAA [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9856173] D'Eustachio, Peter, 2023-12-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360112] R-HSA-71164.7
structureModified[InstanceEdit:9855286] Stephan, Ralf, 2023-12-01
summation[Summation:178870] Cytosolic homogentisate 1,2-dioxygenase (HGD) catalyzes the ...
(hasEvent)[Pathway:8963684] Tyrosine catabolism [Homo sapiens]
(precedingEvent)[Reaction:71173] GSTZ1 isomerizes 4-MAA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791220] Update Tracker - [Reaction:71164] homogentisate + O2 => maleylacetoacetate - v32:[add_removeLiteratureReference, modifyText]
[_UpdateTracker:9864118] Update Tracker - [Reaction:71164] HGD dioxygenates homogentisate - v88:[addLiteratureReference, addOutput, modifyText]
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No pathways have been reviewed or authored by HGD dioxygenates homogentisate (71164)
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