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Details on Person HPD dioxygenates HPP

Class:Id	Reaction:71163
_displayName	HPD dioxygenates HPP
_doRelease	TRUE
_timestamp	2024-11-22 22:11:02
authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:71162] 4-hydroxyphenylpyruvate dioxygenase activity of HPD:AscH-:Fe2+ dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643848] 4-hydroxyphenylpyruvate dioxygenase activity of HPD:AscH-:Fe2+ dimer [cytosol] Mutations in the 4-hydroxyphenylpyruvate dioxygenase gene (HPD) in patients with tyrosinemia type III
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9855288] RHEA:16190
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input	[SimpleEntity:31365] HPP [cytosol] [SimpleEntity:29368] O2 [cytosol]
internalReviewed	[InstanceEdit:9856173] D'Eustachio, Peter, 2023-12-13
literatureReference	[LiteratureReference:517439] Mutations in the 4-hydroxyphenylpyruvate dioxygenase gene (HPD) in patients with tyrosinemia type III [LiteratureReference:9640424] The mechanism of enzymic formation of homogentisate from p-hydroxyphenylpyruvate [LiteratureReference:9855550] The genetic tyrosinemias [LiteratureReference:9855530] Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors [LiteratureReference:9855559] Identification of key residues determining the binding specificity of human 4-hydroxyphenylpyruvate dioxygenase [LiteratureReference:9855533] Functional role of residues involved in substrate binding of human 4-hydroxyphenylpyruvate dioxygenase [LiteratureReference:9855561] Nitisinone in the treatment of hereditary tyrosinaemia type 1 [LiteratureReference:9856172] From toxicological problem to therapeutic use: the discovery of the mode of action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), its toxicology and development as a drug
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:517440] D'Eustachio, P, 2010-02-18 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:1080814] D'Eustachio, P, 2010-11-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8963951] Jassal, Bijay, 2017-02-14 [InstanceEdit:9640422] Jassal, Bijay, 2019-03-26 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9855286] Stephan, Ralf, 2023-12-01 [InstanceEdit:9855555] Stephan, Ralf, 2023-12-04 [InstanceEdit:9856170] Stephan, Ralf, 2023-12-13 [InstanceEdit:9859596] Stephan, Ralf, 2024-01-22 [InstanceEdit:9929230] D'Eustachio, Peter, 2024-11-22
name	HPD dioxygenates HPP 3-(4-hydroxyphenyl)pyruvate + O2 => CO2 + homogentisate p-hydroxyphenylpyruvate + O2 => homogentisate + CO2
output	[SimpleEntity:30337] HGTA [cytosol] [SimpleEntity:113528] CO2 [cytosol]
precedingEvent	[Reaction:71155] TAT deaminates tyrosine [Homo sapiens] [Reaction:71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[NegativeRegulation:9855551] Negative regulation by 'nitisinone:HPD dimer [cytosol]'
regulationReference	[RegulationReference:9856166] Negative regulation by 'nitisinone:HPD dimer [cytosol]' Nitisinone in the treatment of hereditary tyrosinaemia type 1
releaseDate	2004-07-06
reviewed	[InstanceEdit:9856173] D'Eustachio, Peter, 2023-12-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360960] R-HSA-71163.7
structureModified	[InstanceEdit:9855555] Stephan, Ralf, 2023-12-04
summation	[Summation:179028] Cytosolic 4-hydroxyphenylpyruvate dioxygenase (HPD, HPPD) ca...
(hasEvent)	[Pathway:8963684] Tyrosine catabolism [Homo sapiens]
(precedingEvent)	[Reaction:71164] HGD dioxygenates homogentisate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777660] Update Tracker - [Reaction:71163] p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 - v69:[addLiteratureReference, modifyText] [_UpdateTracker:9791237] Update Tracker - [Reaction:71163] p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 - v32:[add_removeLiteratureReference, modifyText] [_UpdateTracker:9864034] Update Tracker - [Reaction:71163] HPD dioxygenates HPP - v88:[addLiteratureReference, addRegulator, modifyText]
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