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Details on Person 4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O

Class:IdReaction:71146
_displayName4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O
_doReleaseTRUE
_timestamp2024-11-22 22:10:57
authored[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity[CatalystActivity:71145] 4-alpha-hydroxytetrahydrobiopterin dehydratase activity of PCBD1 tetramer [cytosol]
catalystActivityReference[CatalystActivityReference:9643835] 4-alpha-hydroxytetrahydrobiopterin dehydratase activity of PCBD1 tetramer [cytosol] Phenyalanine hydroxylase-stimulating protein/pterin-4 alpha-carbinolamine dehydratase from rat and human liver. Purification, characterization, and complete amino acid sequence
compartment[Compartment:70101] cytosol
crossReference[DatabaseIdentifier:9929220] RHEA:11921
edited[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input[SimpleEntity:71112] 4aOH-BH4 [cytosol]
literatureReference[LiteratureReference:71147] Mutation in the 4a-carbinolamine dehydratase gene leads to mild hyperphenylalaninemia with defective cofactor metabolism
[LiteratureReference:71140] Three-dimensional structure of the bifunctional protein PCD/DCoH a cytoplasmic enzyme interacting with the transcription factor HNF1
[LiteratureReference:71133] Phenyalanine hydroxylase-stimulating protein/pterin-4 alpha-carbinolamine dehydratase from rat and human liver. Purification, characterization, and complete amino acid sequence
modified[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:517440] D'Eustachio, P, 2010-02-18
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:1080814] D'Eustachio, P, 2010-11-27
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9929230] D'Eustachio, Peter, 2024-11-22
name4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O
(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin => (6R)-L-erythro-6,7-dihydrobiopterin + H2O
output[SimpleEntity:71129] qDHB [cytosol]
[SimpleEntity:29356] H2O [cytosol]
precedingEvent
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360481] R-HSA-71146.5
summation[Summation:178347] Cytosolic pterin-4-alpha-carbinolamine dehydratase (PCDB1) c...
(hasEvent)[Pathway:8964208] Phenylalanine metabolism [Homo sapiens]
(precedingEvent)[Reaction:71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791008] Update Tracker - [Reaction:71146] 4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O - v32:[add_removeLiteratureReference, modifyText]
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