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Details on Person q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+

Class:Id	Reaction:71130
_displayName	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
_doRelease	TRUE
_timestamp	2024-11-22 22:11:10
authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:71128] 6,7-dihydropteridine reductase activity of QDPR dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9644031] 6,7-dihydropteridine reductase activity of QDPR dimer [cytosol] Structure and expression of human dihydropteridine reductase
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9929218] RHEA:32253
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input	[SimpleEntity:71129] qDHB [cytosol] [SimpleEntity:73473] NADH [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:71121] Structure and expression of human dihydropteridine reductase [LiteratureReference:517451] The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue
modified	[InstanceEdit:113752] Schmidt, EE, 2004-06-21 10:53:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:517440] D'Eustachio, P, 2010-02-18 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:1080814] D'Eustachio, P, 2010-11-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929230] D'Eustachio, Peter, 2024-11-22
name	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+)
output	[SimpleEntity:29870] BH4 [cytosol] [SimpleEntity:29360] NAD+ [cytosol]
precedingEvent	[Reaction:71146] 4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O [Homo sapiens] [Reaction:71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361495] R-HSA-71130.5
summation	[Summation:179128] Cytosolic dihydropteridine reductase (QDPR) catalyzes the re...
(hasEvent)	[Pathway:8964208] Phenylalanine metabolism [Homo sapiens]
(precedingEvent)	[Reaction:71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790936] Update Tracker - [Reaction:71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - v32:[add_removeLiteratureReference, modifyText]
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