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Details on Person alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+

Class:Id	Reaction:71037
_displayName	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
_doRelease	FALSE
_timestamp	2024-04-09 07:34:53
authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:69997] dihydrolipoyl dehydrogenase (NADH) activity of OADH complex [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
figure	[Figure:70727] /figures/oxidative_decarboxylation.jpg
input	[SimpleEntity:70951] 2-OA [mitochondrial matrix] [SimpleEntity:29374] CoA-SH [mitochondrial matrix] [SimpleEntity:113526] NAD+ [mitochondrial matrix]
literatureReference	[LiteratureReference:450848] Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations [LiteratureReference:69983] Structure-function relationships in dihydrolipoamide acyltransferases [LiteratureReference:69985] Subunit interactions in the mammalian alpha-ketoglutarate dehydrogenase complex. Evidence for direct association of the alpha-ketoglutarate dehydrogenase and dihydrolipoamide dehydrogenase components [LiteratureReference:69972] The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:156881] Joshi-Tope, G, 2004-12-14 03:06:51 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:180647] D'Eustachio, P, 2006-05-29 17:18:41 [InstanceEdit:194431] Schmidt, EE, 2007-03-13 12:34:40 [InstanceEdit:376867] D'Eustachio, P, 2008-09-09 22:17:21 [InstanceEdit:376868] D'Eustachio, P, 2008-09-09 22:24:15 [InstanceEdit:451020] D'Eustachio, P, 2009-12-24 [InstanceEdit:451020] D'Eustachio, P, 2009-12-24 [InstanceEdit:508502] D'Eustachio, P, 2010-02-12 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:1080818] D'Eustachio, P, 2010-11-27 [InstanceEdit:2146626] D'Eustachio, P, 2012-02-26 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9858341] Stephan, Ralf, 2024-01-12 [InstanceEdit:9860615] D'Eustachio, Peter, 2024-02-08 [InstanceEdit:9907401] Stephan, Ralf, 2024-04-09
name	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase
output	[SimpleEntity:70955] GL-CoA [mitochondrial matrix] [SimpleEntity:29376] CO2 [mitochondrial matrix] [SimpleEntity:29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:372480] 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] [Homo sapiens] [Reaction:70613] GOT2 transaminates OA and L-Glu [Homo sapiens] [Reaction:508561] alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate [Homo sapiens]
releaseDate	2004-07-06
reviewed	[InstanceEdit:9860616] D'Eustachio, Peter, 2024-02-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361562] R-HSA-71037.4
summation	[Summation:71038] The mitochondrial alpha-ketoglutarate dehydrogenase complex ...
(replacementInstances)	[_Deleted:508505] Deletion of instances: 70956, 70954, 70953
(updatedInstance)	[_UpdateTracker:9788773] Update Tracker - [Reaction:71037] alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ - v40:[modifyText, removeOutput]
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No pathways have been reviewed or authored by alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (71037)