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Details on Person propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate

Class:Id	Reaction:71031
_displayName	propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate
_doRelease	TRUE
_timestamp	2025-12-30 14:35:06
catalystActivity	[CatalystActivity:71030] propionyl-CoA carboxylase activity of 6x(Btn-PCCA:PCCB) [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643743] propionyl-CoA carboxylase activity of 6x(Btn-PCCA:PCCB) [mitochondrial matrix] Isolation and characterization of propionyl-CoA carboxylase from normal human liver. Evidence for a protomeric tetramer of nonidentical subunits
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9978275] RHEA:23721
input	[SimpleEntity:70843] PROP-CoA [mitochondrial matrix] [SimpleEntity:113593] ATP [mitochondrial matrix] [SimpleEntity:29896] HCO3- [mitochondrial matrix]
internalReviewed	[InstanceEdit:9978289] D'Eustachio, Peter, 2025-12-29
literatureReference	[Book:71000] The Metabolic and Molecular Bases of Inherited Disease, 8th ed Scriver, CR Disorders of propionate and methylmalonate metabolism 0079130356 [LiteratureReference:449696] Isolation and characterization of propionyl-CoA carboxylase from normal human liver. Evidence for a protomeric tetramer of nonidentical subunits [LiteratureReference:71027] Metabolism of propionic acid in animal tissues. VIII. Crystalline propionyl carboxylase [LiteratureReference:1112677] Mitochondrial targeting signals and mature peptides of 3-methylcrotonyl-CoA carboxylase
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:164611] D'Eustachio, P, 2005-06-03 13:08:07 [InstanceEdit:449694] D'Eustachio, P, 2009-12-05 [InstanceEdit:1165323] D'Eustachio, P, 2010-12-14 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9978231] D'Eustachio, Peter, 2025-12-29 [InstanceEdit:9978272] D'Eustachio, Peter, 2025-12-29 [InstanceEdit:9978288] D'Eustachio, Peter, 2025-12-29 [InstanceEdit:9978313] D'Eustachio, Peter, 2025-12-30
name	propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
output	[SimpleEntity:71019] MEMA-CoA [mitochondrial matrix] [SimpleEntity:113581] ADP [mitochondrial matrix] [SimpleEntity:113548] Pi [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent	[Reaction:70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA [Homo sapiens] [Reaction:70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Homo sapiens] [Reaction:70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Homo sapiens] [Reaction:70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewed	[InstanceEdit:9978314] D'Eustachio, Peter, 2025-12-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361632] R-HSA-71031.5
structureModified	[InstanceEdit:9978231] D'Eustachio, Peter, 2025-12-29 [InstanceEdit:9978272] D'Eustachio, Peter, 2025-12-29
summation	[Summation:179123] Propionyl CoA carboxylase in the mitochondrial matrix cataly...
(hasEvent)	[Pathway:71032] Propionyl-CoA catabolism [Homo sapiens]
(precedingEvent)	[Reaction:71020] D-methylmalonyl-CoA <=> L-methylmalonyl-CoA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9789904] Update Tracker - [Reaction:71031] propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate - v36:[addLiteratureReference, modifyText] [_UpdateTracker:9790811] Update Tracker - [Reaction:71031] propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate - v32:[addLiteratureReference, modifyText] [_UpdateTracker:9984568] Update Tracker - [Reaction:71031] propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate - v96:[add_removeInput, removeOutput]
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