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Details on Person D-methylmalonyl-CoA <=> L-methylmalonyl-CoA

Class:Id	Reaction:71020
_displayName	D-methylmalonyl-CoA <=> L-methylmalonyl-CoA
_doRelease	TRUE
_timestamp	2025-12-29 22:36:47
catalystActivity	[CatalystActivity:71018] methylmalonyl-CoA epimerase activity of MCEE [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9978267] RHEA:20555
input	[SimpleEntity:71019] MEMA-CoA [mitochondrial matrix]
literatureReference	[Book:71000] The Metabolic and Molecular Bases of Inherited Disease, 8th ed Scriver, CR Disorders of propionate and methylmalonate metabolism 0079130356 [LiteratureReference:71013] Metabolism of propionic acid in animal tissues. IX. Methylmalonyl coenzyme A racemase [LiteratureReference:71015] Identification of the human methylmalonyl-CoA racemase gene based on the analysis of prokaryotic gene arrangements. Implications for decoding the human genome
modified	[InstanceEdit:164611] D'Eustachio, P, 2005-06-03 13:08:07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9978272] D'Eustachio, Peter, 2025-12-29
name	D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA
output	[SimpleEntity:71009] L-MM-CoA [mitochondrial matrix]
precedingEvent	[Reaction:71031] propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate [Homo sapiens] [Reaction:70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA [Homo sapiens] [Reaction:70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361021] R-HSA-71020.4
summation	[Summation:178635] At the beginning of this reaction, 1 molecule of 'D-methylma...
(hasEvent)	[Pathway:71032] Propionyl-CoA catabolism [Homo sapiens]
(precedingEvent)	[Reaction:71010] MUT isomerises L-MM-CoA to SUCC-CoA [Homo sapiens]
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No pathways have been reviewed or authored by D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (71020)