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Details on Person MUT isomerises L-MM-CoA to SUCC-CoA

Class:IdReaction:71010
_displayNameMUT isomerises L-MM-CoA to SUCC-CoA
_doReleaseTRUE
_timestamp2025-12-29 22:36:55
authored[InstanceEdit:3159299] Jassal, Bijay, 2013-02-20
catalystActivity[CatalystActivity:71008] methylmalonyl-CoA mutase activity of 2xMMAA:2xMUT:AdoCbl [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
crossReference[DatabaseIdentifier:9978273] RHEA:22889
edited[InstanceEdit:3159299] Jassal, Bijay, 2013-02-20
input[SimpleEntity:71009] L-MM-CoA [mitochondrial matrix]
literatureReference[LiteratureReference:3159280] Cloning of full-length methylmalonyl-CoA mutase from a cDNA library using the polymerase chain reaction
[LiteratureReference:3159269] Spectrum of mutations in mut methylmalonic acidemia and identification of a common Hispanic mutation and haplotype
[LiteratureReference:3159262] Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation
[LiteratureReference:3159263] Protection and reactivation of human methylmalonyl-CoA mutase by MMAA protein
[LiteratureReference:3159271] Assembly and protection of the radical enzyme, methylmalonyl-CoA mutase, by its chaperone
[LiteratureReference:3159291] Identification of the gene responsible for the cblA complementation group of vitamin B12-responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangements
[LiteratureReference:3159300] Mutations in the MMAA gene in patients with the cblA disorder of vitamin B12 metabolism
modified[InstanceEdit:164611] D'Eustachio, P, 2005-06-03 13:08:07
[InstanceEdit:3159299] Jassal, Bijay, 2013-02-20
[InstanceEdit:3162930] Jassal, Bijay, 2013-02-21
[InstanceEdit:3968436] Jassal, Bijay, 2013-07-24
[InstanceEdit:5099911] Jassal, Bijay, 2013-11-14
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9978272] D'Eustachio, Peter, 2025-12-29
nameMUT isomerises L-MM-CoA to SUCC-CoA
(R)-methylmalonyl-CoA => succinyl-CoA
L-methylmalonyl-CoA <=> succinyl-CoA
output[SimpleEntity:70958] SUCC-CoA [mitochondrial matrix]
precedingEvent
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:3162923] Jassal, Bijay, 2013-02-21
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361326] R-HSA-71010.4
summation[Summation:178927] Methylmalonyl CoA mutase (MUT aka MCM) (Jansen et al. 1989) ...
(hasEvent)[Pathway:71032] Propionyl-CoA catabolism [Homo sapiens]
(normalReaction)[FailedReaction:3322971] Defective MUT does not isomerise L-MM-CoA to SUCC-CoA [Homo sapiens]
(precedingEvent)[Reaction:70997] SUCLG1/A2 cleaves succinyl-CoA [Homo sapiens]
[Reaction:71775] SUCLG1/G2 cleaves succinyl-CoA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786025] Update Tracker - [Reaction:71010] MUT isomerises L-MM-CoA to SUCC-CoA - v50:[modifyText]
[_UpdateTracker:9786882] Update Tracker - [Reaction:71010] MUT isomerises L-MM-CoA to SUCC-CoA - v47:[removeInput, removeOutput]
[_UpdateTracker:9787082] Update Tracker - [Reaction:71010] MUT isomerises L-MM-CoA to SUCC-CoA - v46:[modifyText]
[_UpdateTracker:9787504] Update Tracker - [Reaction:71010] MUT isomerises L-MM-CoA to SUCC-CoA - v45:[modifyText]
[_UpdateTracker:9787957] Update Tracker - [Reaction:71010] MUT isomerises L-MM-CoA to SUCC-CoA - v44:[addInput, addOutput, add_removeLiteratureReference, modifyText]
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