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Details on Person SDH complex dehydrogenates succinate
Class:Id Reaction:70994 _displayName SDH complex dehydrogenates succinate _doRelease TRUE _timestamp 2024-02-15 20:40:56 catalystActivity [CatalystActivity:70993] succinate dehydrogenase (quinone) activity of SDH complex [mitochondrial inner membrane] compartment [Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane crossReference [DatabaseIdentifier:9854209] RHEA:13714 input [SimpleEntity:113536] SUCCA [mitochondrial matrix] [SimpleEntity:73663] CoQ [mitochondrial inner membrane] internalReviewed [InstanceEdit:9856153] D'Eustachio, Peter, 2023-12-12 literatureReference [LiteratureReference:198397] Succinate dehydrogenase deficiency in human [LiteratureReference:9763316] The inhibitory effects of itaconic acid in vitro and in vivo [LiteratureReference:9763331] STUDIES ON SUCCINATE DEHYDROGENASE. I. SPECTRAL PROPERTIES OF THE PURIFIED ENZYME AND FORMATION OF ENZYME-COMPETITIVE INHIBITOR COMPLEXES [LiteratureReference:9763372] Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels [LiteratureReference:9762897] Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation [LiteratureReference:9763328] Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase [LiteratureReference:9763394] Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations [LiteratureReference:9763362] Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF [LiteratureReference:9763373] Hypoxia/pseudohypoxia-mediated activation of hypoxia-inducible factor-1α in cancer [LiteratureReference:8874523] The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase [LiteratureReference:8874501] Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis [LiteratureReference:8874515] Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells modified [InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:156629] D'Eustachio, P, 2004-12-07 23:21:37 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:164648] Jassal, Bijay, 2005-06-10 [InstanceEdit:164935] Jassal, Bijay, 2005-07-22 [InstanceEdit:198405] D'Eustachio, P, 2007-06-18 16:46:57 [InstanceEdit:203945] Gopinathrao, G, 2007-11-19 17:27:54 [InstanceEdit:373130] D'Eustachio, P, 2008-07-14 13:50:27 [InstanceEdit:376847] D'Eustachio, P, 2008-09-08 20:58:44 [InstanceEdit:378936] D'Eustachio, P, 2008-09-26 14:13:17 [InstanceEdit:451044] D'Eustachio, P, 2009-12-26 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9653551] D'Eustachio, Peter, 2019-07-11 [InstanceEdit:9767147] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767546] Rothfels, Karen, 2022-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9853494] Stephan, Ralf, 2023-11-16 [InstanceEdit:9854201] Stephan, Ralf, 2023-11-23 [InstanceEdit:9855620] Stephan, Ralf, 2023-12-05 [InstanceEdit:9856154] Stephan, Ralf, 2023-12-12 [InstanceEdit:9861237] D'Eustachio, Peter, 2024-02-15 name SDH complex dehydrogenates succinate output [SimpleEntity:113588] FUMA [mitochondrial matrix] [SimpleEntity:2162198] CoQH2 [mitochondrial inner membrane] precedingEvent
previousReviewStatus [ReviewStatus:9821385] four stars regulatedBy [NegativeRegulation:8874496] Negative regulation by 'TRAP1 [mitochondrial matrix]' [NegativeRegulation:9854200] Negative regulation by 'itaconate [mitochondrial matrix]' releaseDate 2004-07-06 reviewed [InstanceEdit:9861215] Hill, David P, 2024-02-15 reviewStatus [ReviewStatus:9821382] five stars revised [InstanceEdit:451045] D'Eustachio, P, 2009-12-26 species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:358363] R-HSA-70994.6 structureModified [InstanceEdit:9853494] Stephan, Ralf, 2023-11-16 [InstanceEdit:9854201] Stephan, Ralf, 2023-11-23 summation [Summation:71411] The succinate dehydrogenase complex (SDH, complex II), assoc... (hasEvent) [Pathway:71403] Citric acid cycle (TCA cycle) [Homo sapiens] [Pathway:9767142] NFE2L2 HIF1alpha metabolic reprogramming COV2 [Homo sapiens] (inferredFrom) [Reaction:373129] fumarate + FADH2 <=> succinate + FAD [Gallus gallus] [Reaction:373147] succinate + FAD <=> fumarate + FADH2 [Gallus gallus] (precedingEvent) [Reaction:70982] FH tetramer hydrates fumarate to L-malate [Homo sapiens] (updatedInstance) [_UpdateTracker:9775037] Update Tracker - [Reaction:70994] Succinate <=> Fumarate (with FAD redox reaction on enzyme) - v80:[addLiteratureReference, modifyText] [_UpdateTracker:9792227] Update Tracker - [Reaction:70994] Succinate <=> Fumarate (with FAD redox reaction on enzyme) - v22:[addLiteratureReference, modifyText] [_UpdateTracker:9864278] Update Tracker - [Reaction:70994] SDH complex dehydrogenates succinate - v88:[addInput, addLiteratureReference, addOutput, addRegulator, modifyText]
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