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Details on Person FH tetramer hydrates fumarate to L-malate

Class:IdReaction:70982
_displayNameFH tetramer hydrates fumarate to L-malate
_doReleaseTRUE
_timestamp2024-02-15 20:40:37
catalystActivity[CatalystActivity:70981] fumarate hydratase activity of FH tetramer [mitochondrial matrix]
catalystActivityReference[CatalystActivityReference:9643531] fumarate hydratase activity of FH tetramer [mitochondrial matrix] Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency
compartment[Compartment:5460] mitochondrial matrix
crossReference[DatabaseIdentifier:9854203] RHEA:12460
input[SimpleEntity:113588] FUMA [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
internalReviewed[InstanceEdit:9856153] D'Eustachio, Peter, 2023-12-12
literatureReference[LiteratureReference:198390] Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency
[LiteratureReference:9854194] Structural, biochemical and biophysical characterization of recombinant human fumarate hydratase
[LiteratureReference:9854210] The Pleiotropic Effects of Fumarate: From Mitochondrial Respiration to Epigenetic Rewiring and DNA Repair Mechanisms
[LiteratureReference:9854207] Post-translational Modifications of Fumarase Regulate its Enzyme Activity and Function in Respiration and the DNA Damage Response
modified[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:198405] D'Eustachio, P, 2007-06-18 16:46:57
[InstanceEdit:203945] Gopinathrao, G, 2007-11-19 17:27:54
[InstanceEdit:373130] D'Eustachio, P, 2008-07-14 13:50:27
[InstanceEdit:376847] D'Eustachio, P, 2008-09-08 20:58:44
[InstanceEdit:378936] D'Eustachio, P, 2008-09-26 14:13:17
[InstanceEdit:451044] D'Eustachio, P, 2009-12-26
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9853494] Stephan, Ralf, 2023-11-16
[InstanceEdit:9854201] Stephan, Ralf, 2023-11-23
[InstanceEdit:9856154] Stephan, Ralf, 2023-12-12
[InstanceEdit:9859260] Stephan, Ralf, 2024-01-17
[InstanceEdit:9861237] D'Eustachio, Peter, 2024-02-15
nameFH tetramer hydrates fumarate to L-malate
fumarate + H2O => (S)-malate
output[SimpleEntity:113544] MAL [mitochondrial matrix]
precedingEvent
releaseDate2004-07-06
reviewed[InstanceEdit:9861215] Hill, David P, 2024-02-15
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360106] R-HSA-70982.5
summation[Summation:71412] Mitochondrial fumarate hydratase (FH) tetramer catalyzes the...
(hasEvent)[Pathway:71403] Citric acid cycle (TCA cycle) [Homo sapiens]
(inferredFrom)[Reaction:373145] fumarate + H2O <=> malate [Gallus gallus]
(precedingEvent)[Reaction:70979] MDH2 dimer dehydrogenates MAL [Homo sapiens]
[Reaction:372843] SLC25A10 mediates exchange of malate and phosphate [Homo sapiens]
[Reaction:9012268] ME2 tetramer decarboxylates MAL to PYR [Homo sapiens]
[Reaction:9012349] ME3 tetramer decarboxylates MAL to PYR [Homo sapiens]
(reverseReaction)[Reaction:451033] (S)-Malate <=> Fumarate + H2O [Homo sapiens]
[Reaction:9863537] Clone of (S)-Malate <=> Fumarate + H2O [Homo sapiens]
(updatedInstance)[_UpdateTracker:9790955] Update Tracker - [Reaction:70982] Fumarate + H2O <=> (S)-Malate - v32:[modifyText]
[_UpdateTracker:9792210] Update Tracker - [Reaction:70982] Fumarate + H2O <=> (S)-Malate - v22:[addLiteratureReference, modifyText]
[_UpdateTracker:9864254] Update Tracker - [Reaction:70982] FH tetramer hydrates fumarate to L-malate - v88:[addLiteratureReference, modifyText]
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