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Details on Person MDH2 dimer dehydrogenates MAL

Class:IdReaction:70979
_displayNameMDH2 dimer dehydrogenates MAL
_doReleaseTRUE
_timestamp2025-05-28 08:09:44
catalystActivity[CatalystActivity:70978] L-malate dehydrogenase (NAD+) activity of MDH2 dimer [mitochondrial matrix]
catalystActivityReference[CatalystActivityReference:9643763] L-malate dehydrogenase activity of MDH2 dimer [mitochondrial matrix] An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates
compartment[Compartment:5460] mitochondrial matrix
crossReference[DatabaseIdentifier:9854228] RHEA:21433
edited[InstanceEdit:9859599] Stephan, Ralf, 2024-01-22
input[SimpleEntity:113544] MAL [mitochondrial matrix]
[SimpleEntity:113526] NAD+ [mitochondrial matrix]
internalReviewed[InstanceEdit:9856153] D'Eustachio, Peter, 2023-12-12
literatureReference[LiteratureReference:451039] An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates
[LiteratureReference:198468] Aggregation states of mitochondrial malate dehydrogenase
[LiteratureReference:9854231] Structural Comparison of hMDH2 Complexed with Natural Substrates and Cofactors: The Importance of Phosphate Binding for Active Conformation and Catalysis
[LiteratureReference:9854217] Malate dehydrogenase 2 deficiency is an emerging cause of pediatric epileptic encephalopathy with a recognizable biochemical signature
[LiteratureReference:9854243] Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth
modified[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:198405] D'Eustachio, P, 2007-06-18 16:46:57
[InstanceEdit:198480] D'Eustachio, P, 2007-06-22 14:17:01
[InstanceEdit:203945] Gopinathrao, G, 2007-11-19 17:27:54
[InstanceEdit:376847] D'Eustachio, P, 2008-09-08 20:58:44
[InstanceEdit:378936] D'Eustachio, P, 2008-09-26 14:13:17
[InstanceEdit:451044] D'Eustachio, P, 2009-12-26
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9854222] Stephan, Ralf, 2023-11-23
[InstanceEdit:9856154] Stephan, Ralf, 2023-12-12
[InstanceEdit:9856885] Stephan, Ralf, 2023-12-27
[InstanceEdit:9856910] Stephan, Ralf, 2023-12-28
[InstanceEdit:9857486] Stephan, Ralf, 2024-01-07
[InstanceEdit:9859260] Stephan, Ralf, 2024-01-17
[InstanceEdit:9861237] D'Eustachio, Peter, 2024-02-15
[InstanceEdit:9863536] Stephan, Ralf, 2024-03-01
[InstanceEdit:9953017] Stephan, Ralf, 2025-05-28
[InstanceEdit:9964570] Matthews, Lisa, 2025-08-25
nameMDH2 dimer dehydrogenates MAL
(S)-malate + NAD(+) => H(+) + NADH + oxaloacetate
output[SimpleEntity:113587] OA [mitochondrial matrix]
[SimpleEntity:29362] NADH [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent
releaseDate2004-07-06
reviewed[InstanceEdit:9861215] Hill, David P, 2024-02-15
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358977] R-HSA-70979.7
summation[Summation:71413] Mitochondrial malate dehydrogenase (MDH2) dimer catalyzes th...
(hasEvent)[Pathway:71403] Citric acid cycle (TCA cycle) [Homo sapiens]
[Pathway:9856872] Malate-aspartate shuttle [Homo sapiens]
(inferredFrom)[Reaction:373047] malate + NAD+ <=> oxaloacetate + NADH + H+ [Gallus gallus]
(precedingEvent)[NegativePrecedingEvent:9953018] Futile Cycle: MDH2 dimer dehydrogenates MAL
[Reaction:70613] GOT2 transaminates OA and L-Glu [Homo sapiens]
[Reaction:70975] CS acetylates OA to citrate [Homo sapiens]
[Reaction:71401] OGDH dimer decarboxylates 2-OG [Homo sapiens]
[Reaction:163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Homo sapiens]
[Reaction:9012016] FAHD1 dimer hydrolyses OA to PYR [Homo sapiens]
(reverseReaction)[Reaction:71783] MDH2 dimer reduces OA to MAL [Homo sapiens]
[Reaction:9863545] Clone of MDH2 dimer reduces OA to MAL [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791210] Update Tracker - [Reaction:70979] (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ - v32:[add_removeLiteratureReference, modifyText]
[_UpdateTracker:9792192] Update Tracker - [Reaction:70979] (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ - v22:[addLiteratureReference, modifyText]
[_UpdateTracker:9846856] Update Tracker - [Reaction:70979] (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ - v83:[modifyText]
[_UpdateTracker:9864180] Update Tracker - [Reaction:70979] MDH2 dimer dehydrogenates MAL - v88:[addLiteratureReference, modifyText]
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