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Details on Person CS acetylates OA to citrate

Class:Id	Reaction:70975
_displayName	CS acetylates OA to citrate
_doRelease	TRUE
_timestamp	2024-02-15 20:40:27
catalystActivity	[CatalystActivity:70974] obsolete citrate (Si)-synthase activity of N6,N6,N6-trimethyl-K395-CS dimer [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9854189] RHEA:16846
input	[SimpleEntity:113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:113521] H2O [mitochondrial matrix] [SimpleEntity:113587] OA [mitochondrial matrix]
internalReviewed	[InstanceEdit:9856153] D'Eustachio, Peter, 2023-12-12
literatureReference	[LiteratureReference:9853599] Complexes between mitochondrial enzymes and either citrate synthase or glutamate dehydrogenase [LiteratureReference:198413] Cloning and molecular analysis of the human citrate synthase gene [LiteratureReference:9854357] Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation [LiteratureReference:198427] Interaction between citrate synthase and malate dehydrogenase. Substrate channeling of oxaloacetate [LiteratureReference:9853598] Association of the malate dehydrogenase-citrate synthase metabolon is modulated by intermediates of the Krebs tricarboxylic acid cycle [LiteratureReference:9853591] Krebs cycle metabolon: structural evidence of substrate channeling revealed by cross-linking and mass spectrometry
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:198405] D'Eustachio, P, 2007-06-18 16:46:57 [InstanceEdit:203945] Gopinathrao, G, 2007-11-19 17:27:54 [InstanceEdit:450862] D'Eustachio, P, 2009-12-18 [InstanceEdit:450991] D'Eustachio, P, 2009-12-24 [InstanceEdit:451044] D'Eustachio, P, 2009-12-26 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9853494] Stephan, Ralf, 2023-11-16 [InstanceEdit:9853593] Stephan, Ralf, 2023-11-17 [InstanceEdit:9854201] Stephan, Ralf, 2023-11-23 [InstanceEdit:9854323] Stephan, Ralf, 2023-11-25 [InstanceEdit:9856154] Stephan, Ralf, 2023-12-12 [InstanceEdit:9856906] Stephan, Ralf, 2023-12-28 [InstanceEdit:9861237] D'Eustachio, Peter, 2024-02-15 [InstanceEdit:9863268] Stephan, Ralf, 2024-02-28
name	CS acetylates OA to citrate acetyl-CoA + H2O + oxaloacetate => citrate + CoA + H(+)
output	[SimpleEntity:29654] CIT [mitochondrial matrix] [SimpleEntity:29374] CoA-SH [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent	[Reaction:70979] MDH2 dimer dehydrogenates MAL [Homo sapiens] [Reaction:70982] FH tetramer hydrates fumarate to L-malate [Homo sapiens] [Reaction:376851] SLC25A11 exchanges 2-OG and MAL [Homo sapiens] [Reaction:70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA [Homo sapiens] [Reaction:70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Homo sapiens] [Reaction:9854315] CSKMT methylates Citrate Synthase [Homo sapiens] [Reaction:70501] PC carboxylates PYR to OA [Homo sapiens] [Reaction:372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix [Homo sapiens] [Reaction:9012016] FAHD1 dimer hydrolyses OA to PYR [Homo sapiens] [Reaction:9012268] ME2 tetramer decarboxylates MAL to PYR [Homo sapiens] [Reaction:9012349] ME3 tetramer decarboxylates MAL to PYR [Homo sapiens] [Reaction:9861667] DLAT trimer transfers acetyl to CoA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359877] R-HSA-70975.4
structureModified	[InstanceEdit:9853494] Stephan, Ralf, 2023-11-16
summation	[Summation:71414] Mitochondrial citrate synthase (CS) dimer catalyzes the irre...
(hasEvent)	[Pathway:71403] Citric acid cycle (TCA cycle) [Homo sapiens]
(precedingEvent)	[Reaction:70971] ACO2 isomerizes citrate [Homo sapiens] [Reaction:75849] SLC25A1 exchanges CIT and MAL [Homo sapiens] [Reaction:9853512] DLST transfers succinyl to CoA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791124] Update Tracker - [Reaction:70975] Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA - v32:[addLiteratureReference, modifyText] [_UpdateTracker:9792277] Update Tracker - [Reaction:70975] Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA - v22:[addLiteratureReference, modifyText] [_UpdateTracker:9864128] Update Tracker - [Reaction:70975] CS acetylates OA to citrate - v88:[addLiteratureReference, addOutput, modifyText]
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