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Details on Person IDH3 complex decarboxylates isocitrate

Class:IdReaction:70967
_displayNameIDH3 complex decarboxylates isocitrate
_doReleaseTRUE
_timestamp2024-02-15 20:40:41
catalystActivity[CatalystActivity:70966] isocitrate dehydrogenase (NAD+) activity of IDH3 octamer [mitochondrial matrix]
catalystActivityReference[CatalystActivityReference:9643803] isocitrate dehydrogenase (NAD+) activity of IDH3 octamer [mitochondrial matrix] Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase
compartment[Compartment:5460] mitochondrial matrix
crossReference[DatabaseIdentifier:9854202] RHEA:23633
input[SimpleEntity:29938] ISCIT [mitochondrial matrix]
[SimpleEntity:113526] NAD+ [mitochondrial matrix]
internalReviewed[InstanceEdit:9856153] D'Eustachio, Peter, 2023-12-12
literatureReference[LiteratureReference:450990] Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase
[LiteratureReference:1165318] Each conserved active site tyr in the three subunits of human isocitrate dehydrogenase has a different function
[LiteratureReference:198407] Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase
[LiteratureReference:451003] Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase
[LiteratureReference:450998] Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle
[LiteratureReference:9855610] Diphosphopyridine nucleotide dependent isocitrate dehydrogenase from pig heart. Charactgerization of the active substrate and modes of regulation
[LiteratureReference:9855605] Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase
modified[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:198405] D'Eustachio, P, 2007-06-18 16:46:57
[InstanceEdit:203945] Gopinathrao, G, 2007-11-19 17:27:54
[InstanceEdit:373130] D'Eustachio, P, 2008-07-14 13:50:27
[InstanceEdit:376847] D'Eustachio, P, 2008-09-08 20:58:44
[InstanceEdit:378936] D'Eustachio, P, 2008-09-26 14:13:17
[InstanceEdit:450991] D'Eustachio, P, 2009-12-24
[InstanceEdit:451028] D'Eustachio, P, 2009-12-26
[InstanceEdit:451044] D'Eustachio, P, 2009-12-26
[InstanceEdit:451051] D'Eustachio, P, 2009-12-26
[InstanceEdit:1165317] D'Eustachio, P, 2010-12-14
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9853494] Stephan, Ralf, 2023-11-16
[InstanceEdit:9853615] Stephan, Ralf, 2023-11-17
[InstanceEdit:9853653] Stephan, Ralf, 2023-11-20
[InstanceEdit:9854201] Stephan, Ralf, 2023-11-23
[InstanceEdit:9855608] Stephan, Ralf, 2023-12-05
[InstanceEdit:9856154] Stephan, Ralf, 2023-12-12
[InstanceEdit:9861237] D'Eustachio, Peter, 2024-02-15
nameIDH3 complex decarboxylates isocitrate
D-threo-isocitrate + NAD(+) => 2-oxoglutarate + CO2 + NADH
output[SimpleEntity:113594] 2OG [mitochondrial matrix]
[SimpleEntity:29376] CO2 [mitochondrial matrix]
[SimpleEntity:29362] NADH [mitochondrial matrix]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
regulatedBy[Requirement:9853613] Requirement by 'ADP [mitochondrial matrix]'
[NegativeRegulation:9853611] Negative regulation by 'ATP [mitochondrial matrix]'
[NegativeRegulation:9853602] Negative regulation by 'NADH [mitochondrial matrix]'
regulationReference[RegulationReference:9853617] Requirement by 'ADP [mitochondrial matrix]' Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase
releaseDate2004-07-06
reviewed[InstanceEdit:9861215] Hill, David P, 2024-02-15
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359093] R-HSA-70967.6
structureModified[InstanceEdit:9853494] Stephan, Ralf, 2023-11-16
summation[Summation:71416] Mitochondrial isocitrate dehydrogenase IDH3 catalyzes the ir...
(hasEvent)[Pathway:71403] Citric acid cycle (TCA cycle) [Homo sapiens]
(inferredFrom)[Reaction:373024] isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+ [Gallus gallus]
(precedingEvent)[Reaction:71401] OGDH dimer decarboxylates 2-OG [Homo sapiens]
[Reaction:163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Homo sapiens]
[Reaction:1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol [Homo sapiens]
[Reaction:1237047] CA4:Zn2+ hydrates CO2 to HCO3- [Homo sapiens]
[Reaction:1237069] RHAG transports CO2 from extracellular region to cytosol [Homo sapiens]
[Reaction:1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane) [Homo sapiens]
[Reaction:1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) [Homo sapiens]
[Reaction:1475032] Carbonic anhydrase hydrates carbon dioxide (mitochondria) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9789965] Update Tracker - [Reaction:70967] isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] - v36:[addLiteratureReference, modifyText]
[_UpdateTracker:9791038] Update Tracker - [Reaction:70967] isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] - v32:[addLiteratureReference, addRegulator, modifyText]
[_UpdateTracker:9792386] Update Tracker - [Reaction:70967] isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] - v22:[addLiteratureReference, modifyText]
[_UpdateTracker:9864316] Update Tracker - [Reaction:70967] IDH3 complex decarboxylates isocitrate - v88:[addLiteratureReference, addRegulator, modifyText, removeOutput]
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