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Details on Person alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate

Class:Id	Reaction:70952
_displayName	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
_doRelease	TRUE
_timestamp	2024-11-22 22:11:07
authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:70950] L-2-aminoadipate:2-oxoglutarate transaminase activity of AADAT dimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643448] 2-aminoadipate transaminase activity of AADAT dimer [mitochondrial matrix] Crystal structure of human kynurenine aminotransferase II
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9929212] RHEA:12602
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input	[SimpleEntity:113594] 2OG [mitochondrial matrix] [SimpleEntity:508531] 2AMA [mitochondrial matrix]
literatureReference	[LiteratureReference:70944] Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT) [LiteratureReference:508552] Crystal structure of human kynurenine aminotransferase II [LiteratureReference:508560] Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:508502] D'Eustachio, P, 2010-02-12 [InstanceEdit:508568] D'Eustachio, P, 2010-02-12 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:1080818] D'Eustachio, P, 2010-11-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9908862] Stephan, Ralf, 2024-04-23 [InstanceEdit:9929230] D'Eustachio, Peter, 2024-11-22
name	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate 2-oxoglutarate + L-2-aminoadipate => 2-oxoadipate + L-glutamate
negativePrecedingEvent	[NegativePrecedingEvent:9908860] Futile Cycle: alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
output	[SimpleEntity:113552] L-Glu [mitochondrial matrix] [SimpleEntity:70951] 2-OA [mitochondrial matrix]
precedingEvent	[Reaction:70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ [Homo sapiens] [Reaction:70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Homo sapiens] [Reaction:5696408] PXLP-K278-PHYKPL tetramer hydrolyses 5PHL [Homo sapiens] [BlackBoxEvent:9960428] 2AMAS transport from peroxisome to mitochondrial matrix [Homo sapiens]
releaseDate	2004-07-06
reverseReaction	[Reaction:508561] alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate [Homo sapiens] [Reaction:70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate [Homo sapiens]
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358320] R-HSA-70952.6
summation	[Summation:178458] Kynurenine/alpha-aminoadipate aminotransferase (AADAT) catal...
(hasEvent)	[Pathway:71064] Lysine catabolism [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9908861] Futile Cycle: alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate [Reaction:9858321] DHTKD1 dimer decarboxylates 2-OA [Homo sapiens]
(reverseReaction)	[Reaction:508561] alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791064] Update Tracker - [Reaction:70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (70952)