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Details on Person UniProt:Q8N5Z0 AADAT
| Class:Id | ReferenceGeneProduct:70942 |
|---|---|
| _chainChangeLog | transit peptide:1-29 added on Sat February 7 2015;chain:30-425 added on Sat February 7 2015 |
| _displayName | UniProt:Q8N5Z0 AADAT |
| _timestamp | 2025-02-21 19:56:06 |
| chain | transit peptide:1-29 chain:30-425 |
| checksum | 448CCAAB2173A7BA |
| comment | FUNCTION Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).CATALYTIC ACTIVITY glycine + 2-oxoglutarate = glyoxylate + L-glutamateCATALYTIC ACTIVITY L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2OCATALYTIC ACTIVITY L-kynurenine + glyoxylate = kynurenate + glycine + H2OCATALYTIC ACTIVITY 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2OCATALYTIC ACTIVITY 2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + kynurenate + H2OCATALYTIC ACTIVITY 3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2OCATALYTIC ACTIVITY 4-methylsulfanyl-2-oxobutanoate + L-kynurenine = kynurenate + L-methionine + H2OCATALYTIC ACTIVITY 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2OCATALYTIC ACTIVITY indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2OCATALYTIC ACTIVITY 2-oxopentanoate + L-kynurenine = L-2-aminopentanoate + kynurenate + H2OCATALYTIC ACTIVITY 4-methyl-2-oxopentanoate + L-kynurenine = kynurenate + L-leucine + H2OCATALYTIC ACTIVITY L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamateCATALYTIC ACTIVITY glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycineCATALYTIC ACTIVITY L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycineCATALYTIC ACTIVITY L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycineCATALYTIC ACTIVITY glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycineCATALYTIC ACTIVITY L-tryptophan + glyoxylate = indole-3-pyruvate + glycineCATALYTIC ACTIVITY L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycineCATALYTIC ACTIVITY 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2OCATALYTIC ACTIVITY 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2OCOFACTOR Kynurenine transaminase activity is competitively inhibited by aminoadipate, asparagine, glutamate, histidine, cysteine, lysine, 3-hydroxy-kynurenine and phenylalanine.BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 7-9.PATHWAY Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 4/6.SUBUNIT Homodimer.SUBCELLULAR LOCATION Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary.MISCELLANEOUS May be due to a competing donor splice site.SIMILARITY Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. |
| description | recommendedName: fullName evidence="10"Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial shortName: KAT/AadAT alternativeName: 2-aminoadipate aminotransferase alternativeName: 2-aminoadipate transaminase ecNumber evidence="5 8"2.6.1.39 alternativeName: Alpha-aminoadipate aminotransferase shortName: AadAT alternativeName: fullName evidence="10"Glycine transaminase AADAT ecNumber evidence="8"2.6.1.4 alternativeName: Kynurenine aminotransferase II alternativeName: fullName evidence="10"Kynurenine--glyoxylate transaminase AADAT ecNumber evidence="8"2.6.1.63 alternativeName: Kynurenine--oxoglutarate aminotransferase II alternativeName: Kynurenine--oxoglutarate transaminase 2 ecNumber evidence="6 8"2.6.1.7 alternativeName: Kynurenine--oxoglutarate transaminase II alternativeName: fullName evidence="10"Methionine--glyoxylate transaminase AADAT ecNumber evidence="8"2.6.1.73 |
| geneName | AADAT KAT2 KYAT2 |
| identifier | Q8N5Z0 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Aminotransferase Mitochondrion Proteomics identification Pyridoxal phosphate Reference proteome Transferase Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | AADAT |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962094] ENSEMBL:ENSG00000109576 AADAT [Homo sapiens] |
| secondaryIdentifier | AADAT_HUMAN B3KP84 Q9UL02 |
| sequenceLength | 425 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:143855] UniProt:Q8N5Z0-2 AADAT [Homo sapiens] [ReferenceIsoform:411312] UniProt:Q8N5Z0-1 AADAT [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:70943] PXLP-AADAT [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:9972878] PXLP-AADAT [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:508530] N6-pyridoxal phosphate-L-lysine at 263 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8N5Z0 AADAT (70942)
