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Details on Person saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+

Class:IdReaction:70940
_displayNamesaccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+
_doReleaseTRUE
_timestamp2024-10-29 21:41:18
authored[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity[CatalystActivity:70937] saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity of AASS tetramer [mitochondrial matrix]
catalystActivityReference[CatalystActivityReference:9643995] saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity of AASS tetramer [mitochondrial matrix] Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities
compartment[Compartment:5460] mitochondrial matrix
crossReference[DatabaseIdentifier:9925997] RHEA:24521
edited[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input[SimpleEntity:30176] SACN [mitochondrial matrix]
[SimpleEntity:113526] NAD+ [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
literatureReference[LiteratureReference:70926] Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities
[LiteratureReference:70929] Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia
modified[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:449693] D'Eustachio, P, 2009-12-05
[InstanceEdit:508568] D'Eustachio, P, 2010-02-12
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:1080818] D'Eustachio, P, 2010-11-27
[InstanceEdit:6783885] Jassal, Bijay, 2015-06-17
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9925993] D'Eustachio, Peter, 2024-10-29
namesaccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+
H2O + L-saccharopine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH
AASS tetramer oxidises SACN to 2AMAS
output[SimpleEntity:113556] 2AMAS [mitochondrial matrix]
[SimpleEntity:113552] L-Glu [mitochondrial matrix]
[SimpleEntity:29362] NADH [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359608] R-HSA-70940.6
summation[Summation:179169] The saccharopine dehydrogenase activity of lysine-ketoglutar...
(hasEvent)[Pathway:71064] Lysine catabolism [Homo sapiens]
(precedingEvent)[Reaction:70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ [Homo sapiens]
[Reaction:508561] alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate [Homo sapiens]
(updatedInstance)[_UpdateTracker:9790826] Update Tracker - [Reaction:70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - v32:[modifyText, removeLiteratureReference]
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No pathways have been reviewed or authored by saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (70940)
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